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Phase 1 Study of Intratumoral Administration of VAX014 With Expansion in Combination With a Checkpoint Inhibitor in Subjects With Advanced Solid Tumors

for
Advanced Solid Tumor,
Location: Boston MA, Lebanon NH, Morristown NJ,
Sponsor: Vaxiion Therapeutics

Sex: All

Age: 18+

Code: NCT05901285

Phase1, Recruiting

A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

for
Metastatic Solid Tumor, Advanced Solid Tumor,
Location: Boston MA, New York NY, Fairfax VA, Miami FL,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06561685

Phase1, Recruiting

A Study of ASP3082 in Adults With Advanced Solid Tumors

for
Solid Tumor
Location: Boston MA, New Haven CT, New York NY, Hackensack NJ,
Sponsor: Astellas Pharma Inc

Sex: All

Age: 18+

Code: NCT05382559

Phase1, Recruiting

A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

for
KRAS G12C Mutation, KRAS G12S Mutation,
Location: Boston MA, Philadelphia PA, Fairfax VA, Jacksonville FL,
Sponsor: Kumquat Biosciences Inc.

Sex: All

Age: 18+

Code: NCT06720987

Phase1, Recruiting

SLV-154 Treatment of Advanced Cancers

for
Advanced Cancer, Advanced Solid Tumor, Metastatic Cancer
Location: New York NY, East Brunswick NJ, Cleveland OH,
Sponsor: Solve Therapeutics

Sex: All

Age: 12+

Code: NCT06771219

Phase1, Recruiting

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ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR)

for
Locally Advanced Solid Tumor, Metastatic Solid Tumor
Location: Nashville TN, Dallas TX, Denver CO, San Diego CA
Sponsor: Acepodia Biotech, Inc.

Sex: All

Age: 18+

Code: NCT06415487

Phase1, Recruiting

Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

for
Head and Neck Cancers- Squamous Cell, Head and Neck Cancer,
Location: Stanford CA
Sponsor: VLP Therapeutics

Sex: All

Age: 18+

Code: NCT06736379

Phase1, Recruiting

A Non-interventional, International, Multicentre Clinical Research Study to Build the Largest Collection of Multimodal Data (Including Clinical Data, Imaging Data and Omics Data) in Oncology

for
Diffuse Large B Cell Lymphoma, Solid Tumor Cancer
Location: Pittsburgh PA
Sponsor: OWKIN

Sex: All

Age: 18+

Code: NCT06625203

Recruiting

Safety, Pharmacokinetics, and Clinical Activity of LP-284 in Adult Patients With Relapsed or Refractory Lymphomas and Solid Tumors

for
Relapsed or Refractory Lymphomas, Advanced Solid Tumor
Location: West Valley City UT
Sponsor: Lantern Pharma Inc.

Sex: All

Age: 18+

Code: NCT06132503

Phase1, Recruiting

A Study of PARP1 Selective Inhibitor, EIK1004 (IMP1707) in Participants With Advanced Solid Tumors.

for
Advanced Solid Tumors
Location: Boston MA, Fairfax VA, Lake Mary FL, Denver CO,
Sponsor: Eikon Therapeutics

Sex: All

Age: 18 - 70+

Code: NCT06907043

Phase1, Phase2, Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

for
Advanced Solid Tumor, Advanced Malignant Neoplasm,
Location: Boston MA, New Haven CT, New York NY, Philadelphia PA,
Sponsor: PMV Pharmaceuticals, Inc

Sex: All

Age: 12+

Code: NCT04585750

Phase1, Phase2, Recruiting

Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy

for
B-ALL, Hematologic Malignancy, Solid Tumor
Location: Philadelphia PA, Milwaukee WI, Memphis TN, Aurora CO,
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 30

Code: NCT06579469

Recruiting

A Study of XB628 Alone and in Combination With Zanzalintinib in Participants With Recurrent Advanced or Metastatic Solid Tumors

for
Solid Tumor, Advanced Solid Tumor, Metastatic Solid Tumor,
Location: Boston MA, New Haven CT, New York NY, Hickory NC,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT06952010

Phase1, Recruiting

ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours

for
Advanced Solid Tumor, PDAC, HNSCC
Location: Boston MA, New Haven CT, New York NY, St Louis MO,
Sponsor: Adcendo ApS

Sex: All

Age: 18+

Code: NCT06597721

Phase1, Recruiting

Study of IBI3020 Treatment in Participants With Late-Stage Solid Tumors

for
Solid Tumors
Location: New York NY, Jacksonville FL, Rochester MN, Houston TX,
Sponsor: Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD.

Sex: All

Age: 18 - 70+

Code: NCT06963281

Phase1, Recruiting

Safety and Preliminary Efficacy of VIR-5525 and VIR-5525 + Pembrolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

for
Solid Tumor Malignancies, EGFR Positive Solid Tumors, EGFR
Location: Houston TX, Scottsdale AZ
Sponsor: Vir Biotechnology, Inc.

Sex: All

Age: 18+

Code: NCT06960395

Phase1, Recruiting

Discovering Novel Cancer Treatment Options Using a Comprehensive NGS-based Liquid Molecular Testing Panel in the Community Setting ("DINOSAur II")

for
Stage III Solid Tumors, Stage IV Solid Tumors
Location: Glendale CA
Sponsor: Glendale Adventist Medical Center d/b/a Adventist Health Glendale

Sex: All

Age: 18+

Code: NCT05703243

Recruiting

Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and in Patients With Other Advanced Solid Tumors

for
Advanced HR+/HER2- Breast Cancer,
Location: Boston MA, New York NY, Montreal, Toronto,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18 - 70+

Code: NCT06726148

Phase1, Phase2, Recruiting

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

for
Solid Tumors, Advanced Cancer, Renal Cancer, Gastric Cancer,
Location: Montreal, Hershey PA, Chapel Hill NC, Toronto,
Sponsor: Apollomics Inc.

Sex: All

Age: 18+

Code: NCT03175224

Phase2, Recruiting

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

for
Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors
Location: Augusta ME, Brewer ME, Rockport ME, Belfast ME,
Sponsor: American Society of Clinical Oncology

Sex: All

Age: 12+

Code: NCT02693535

Phase2, Recruiting