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Active & Responsive

Optimizing Ancillary Therapies With Immune Checkpoint Inhibitors for Solid Tumors (OAT ICI)

for
Solid Tumors
Location: Lexington KY
Sponsor: Val Adams

Sex: All

Age: 18 - 70+

Code: NCT07661459

Phase2, Recruiting
Active & Responsive

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

for
Solid Tumors
Location: New York NY, Baltimore MD, Atlanta GA
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT07492680

Phase2, Recruiting
Active & Responsive

Metronomic Gemcitabine, Mitomycin C, and Thalidomide for Advanced Solid Tumors

for
Solid Tumor Cancer
Location: Santa Monica CA
Sponsor: Sarcoma Oncology Research Center, LLC

Sex: All

Age: 18+

Code: NCT07671534

Phase2, Recruiting
Active & Responsive

A Study of NEOK001, a B7-H3 and ROR1 Targeting Bispecific ADC in Participants With Select Solid Tumors

for
Locally Advanced (Unresectable) or Metastatic Solid Tumors
Location: New York NY, Fairfax VA, Nashville TN, Houston TX,
Sponsor: NEOK Bio, Inc.

Sex: All

Age: 18+

Code: NCT07612176

Phase1, Recruiting
Active & Responsive

A Study of IDE849 in Patients With DLL3 Expressing Tumors Including Small Cell Lung Cancer

for
Small-cell Lung Cancer, Neuroendocrine Carcinomas,
Location: New York NY, Philadelphia PA, Fairfax VA, Orlando FL,
Sponsor: IDEAYA Biosciences

Sex: All

Age: 18+

Code: NCT07174583

Phase1, Phase2, Recruiting

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Active & Responsive

GTB-5550 in Advanced Solid Tumors

for
Tri-specific Killer Engager, Solid Tumor, Advanced Solid Tumor
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 18+

Code: NCT07541573

Phase1, Recruiting
Active & Responsive

ARC101 in Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Montreal, Toronto, Grand Rapids MI, San Antonio TX,
Sponsor: Third Arc Bio

Sex: All

Age: 18+

Code: NCT06672185

Phase1, Recruiting
Active & Responsive

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

for
Solid Tumor Malignancies, Colorectal Carcinoma,
Location: Philadelphia PA, Fairfax VA, Orlando FL,
Sponsor: Tasca Therapeutics

Sex: All

Age: 18+

Code: NCT07030257

Phase1, Phase2, Recruiting
Active & Responsive

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

for
Solid Tumor, Non-Small-Cell Lung Cancer,
Location: New York NY, Hackensack NJ, Fairfax VA, Buffalo NY,
Sponsor: Astellas Pharma Inc

Sex: All

Age: 18+

Code: NCT07094204

Phase1, Recruiting
Active & Responsive

A Study of ERAS-4001 in Patients With Advanced or Metastatic Solid Tumors.

for
Metastatic Solid Tumors
Location: Nashville TN, Houston TX, Irving TX, San Antonio TX,
Sponsor: Erasca, Inc.

Sex: All

Age: 18 - 70+

Code: NCT07021898

Phase1, Recruiting
Active & Responsive

A Study to Investigate the Safety and Efficacy of KQB168 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

for
Solid Tumor Malignancies
Location: New Haven CT, Fairfax VA, Jacksonville FL, Sarasota FL,
Sponsor: Kumquat Biosciences Inc.

Sex: All

Age: 18+

Code: NCT06994806

Phase1, Recruiting
Active & Responsive

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

for
Breast Cancer, Endometrial Cancer, Ovarian Cancer,
Location: Boston MA, Fairfax VA, Orlando FL, Cleveland OH,
Sponsor: Terremoto Biosciences Inc.

Sex: All

Age: 18+

Code: NCT07109726

Phase1, Phase2, Recruiting
Active & Responsive

Mayo Clinic Radiotherapy Patient Outcomes Registry and Biobanking Study

for
Solid Tumors, Hematologic Malignancies
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 0+

Code: NCT02457962

Recruiting
Active & Responsive

Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmocodynamics and Preliminary Antitumor Activity of AT-1965 in Patients With Advanced, Refractory or Recurrent Solid Tumors

for
Solid Tumor
Location: Dallas TX, Scottsdale AZ, Portland OR, El Segundo CA,
Sponsor: Alyssum Therapeutics

Sex: All

Age: 18+

Code: NCT06234098

Phase1, Phase2, Recruiting
Active & Responsive

A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

for
Advanced Solid Tumors
Location: Moncton, Hackensack NJ, Fairfax VA, Kingston, Toronto,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT05067283

Phase1, Recruiting
Active & Responsive

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Boston MA, New York NY, Hackensack NJ,
Sponsor: ModernaTX, Inc.

Sex: All

Age: 12+

Code: NCT05533697

Phase1, Phase2, Recruiting
Active & Responsive

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

for
Head and Neck Carcinoma, Adenoid Cystic Carcinoma, Lung Cancer,
Location: Hartford CT, New York NY, Englewood NJ, Florham Park NJ,
Sponsor: VM Oncology, LLC

Sex: All

Age: 18 - 70+

Code: NCT03556228

Phase1, Phase2, Recruiting
Active & Responsive

Leflunomide in Patients With PTEN-Altered Advanced Solid Malignancies and HER2 Negative Breast Cancer

for
PTEN-Altered Advanced Solid Tumors and HER2 Negative Breast Cancer,
Location: New York NY
Sponsor: Deborah Doroshow

Sex: All

Age: 18+

Code: NCT04997993

Phase1, Recruiting
Active & Responsive

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

for
Non-small Cell Lung Cancer, Histiocytic Neoplasm, Histiocytosis,
Location: Boston MA, New Haven CT, New York NY, Fairfax VA,
Sponsor: Institut de Recherches Internationales Servier

Sex: All

Age: 18+

Code: NCT05786924

Phase1, Phase2, Recruiting
Active & Responsive

A Study of ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors

for
Metastatic Solid Tumors
Location: Boston MA, New York NY, Fairfax VA, Tampa FL,
Sponsor: Erasca, Inc.

Sex: All

Age: 18 - 70+

Code: NCT06983743

Phase1, Recruiting