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Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

for
Neuroblastoma, Ewing Sarcoma, Osteosarcoma, Rhabdomyosarcoma,
Location: Providence RI, Hartford CT, Hackensack NJ, Montreal,
Sponsor: Milton S. Hershey Medical Center

Sex: All

Age: 0 - 30

Code: NCT06541262

Phase1, Phase2, Recruiting

Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

for
Liver Cancer, Rhabdomyosarcoma, Malignant Rhabdoid Tumor,
Location: Houston TX
Sponsor: Baylor College of Medicine

Sex: All

Age: 1 - 21

Code: NCT04715191

Phase1, Recruiting

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in Patients With Advanced Solid Tumor

for
Neoplasms, Tenosynovial Giant Cell Tumor
Location: Beverly Hills CA
Sponsor: Abbisko Therapeutics Co, Ltd

Sex: All

Age: 18+

Code: NCT04192344

Phase1, Recruiting

A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

for
Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung,
Location: Boston MA, Montreal, Baltimore MD, Ottawa, Toronto,
Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All

Age: 18+

Code: NCT06131840

Phase1, Recruiting

Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

for
Anatomic Stage III Breast Cancer AJCC v8,
Location: Boston MA, Pittsburgh PA, Houston TX, Newport Beach CA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 12+

Code: NCT05372640

Phase1, Recruiting

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Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

for
Ewing Sarcoma, Rhabdomyosarcoma, Wilms Tumor, Neuroblastoma,
Location: Valhalla NY
Sponsor: New York Medical College

Sex: All

Age: 1 - 30

Code: NCT04308330

Phase1, Recruiting

Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease

for
Muscle-Invasive Bladder Carcinoma,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT06529822

Phase1, Recruiting

Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

for
Colorectal Neoplasms, Gastric Neoplasms, Cholangiocarcinoma,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 2+

Code: NCT01915225

Recruiting

The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors

for
Non-Small-Cell Lung Carcinoma, Malignant Melanoma,
Location: Elizabethtown KY
Sponsor: VastBiome

Sex: All

Age: 18+

Code: NCT05037825

Recruiting

A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

for
Gastrointestinal Stromal Tumors, Small-cell Lung Cancer,
Location: Cleveland OH, Ann Arbor MI, Houston TX, Portland OR
Sponsor: Novelty Nobility, Inc.

Sex: All

Age: 18+

Code: NCT06805825

Phase1, Recruiting

A Study of TSN1611 Treating Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation

for
Malignant Neoplasm
Location: Fairfax VA, Houston TX, San Antonio TX
Sponsor: Tyligand Pharmaceuticals (Suzhou) Limited

Sex: All

Age: 18 - 70+

Code: NCT06385925

Phase1, Phase2, Recruiting

Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies

for
Castrate Resistant Prostate Cancer, NUT Carcinoma,
Location: Boston MA, Jacksonville FL, Rochester MN, Houston TX,
Sponsor: Epigenetix, Inc.

Sex: All

Age: 18+

Code: NCT05488548

Phase1, Recruiting

A Dose Escalation With Expansion Study of EMB-01 in Participants With Advanced/Metastatic Solid Tumors

for
Neoplasms, Neoplasm Metastasis, Non-Small-Cell Lung Cancer
Location: Boston MA, Canton OH, Detroit MI
Sponsor: Shanghai EpimAb Biotherapeutics Co., Ltd.

Sex: All

Age: 18+

Code: NCT03797391

Phase1, Phase2, Recruiting

First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies

for
Triple Negative Breast Cancer, Hormone-Resistant Breast Cancer,
Location: Baltimore MD
Sponsor: A&G Pharmaceutical Inc.

Sex: All

Age: 18+

Code: NCT05627960

Phase1, Recruiting

Study of [212Pb]Pb-DOTAM-MAM279 ([212Pb]Pb-MP0712) in Patients With Small Cell Lung Cancer and Other DLL3 Expressing Solid Tumors

for
Large Cell Neuroendocrine Carcinoma,
Location: Princeton NJ, Glen Burnie MD, Cleveland OH, Atlanta GA,
Sponsor: Molecular Partners AG

Sex: All

Age: 18+

Code: NCT07278479

Phase1, Phase2, Recruiting

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

for
Advanced Breast Carcinoma, Advanced Endometrial Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05092373

Phase1, Recruiting

A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors

for
ER+ HER2- Advanced Breast Cancer,
Location: Providence RI, Nashville TN, St Louis MO, Houston TX
Sponsor: AstraZeneca

Sex: Female

Age: 18+

Code: NCT06188520

Phase1, Phase2, Recruiting

A Study of DM002 in Patients With Advanced Solid Tumors

for
Ovarian Neoplasms, Prostatic Neoplasms, Endometrial Neoplasms,
Location: Huntersville NC, Houston TX, Oklahoma City OK,
Sponsor: Xadcera Biopharmaceutical (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT06751329

Phase1, Phase2, Recruiting

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

for
Melanoma (Skin Cancer),
Location: Lake Success NY, Fairfax VA, Detroit MI, Cincinnati OH,
Sponsor: Aminex Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07287917

Phase1, Phase2, Recruiting

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

for
Adenocarcinoma, Basal Cell Carcinoma, Squamous Cell Carcinoma,
Location: Orange CA
Sponsor: University of California, Irvine

Sex: All

Age: 18+

Code: NCT07628634

Early_phase1, Recruiting