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Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

for
Advanced Biliary Tract Carcinoma,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT07405086

Recruiting

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

for
Non-Small-Cell Lung, Esophageal Cancer, Cutaneous Melanoma
Location: New Haven CT, Trumbull CT, Fairfax VA, Nashville TN,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07519655

Phase1, Recruiting

A Phase 1 Study of D3S-003 as Monotherapy in Participants With Advanced Solid Tumors With a KRAS p.G12D Mutation.

for
KRAS P.G12D
Location: New Haven CT, Houston TX, San Antonio TX
Sponsor: D3 Bio (Wuxi) Co., Ltd

Sex: All

Age: 18+

Code: NCT07456046

Phase1, Recruiting

A Study of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors

for
Thoracic Neoplasms, Lung Diseases, Small Cell Lung Carcinoma
Location: Washington D.C. DC, Fairfax VA, Plantation FL,
Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT07407933

Phase1, Phase2, Recruiting

A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types

for
Esophageal Squamous Cell Carcinoma,
Location: Lake Success NY, Fairfax VA, Sarasota FL, Detroit MI,
Sponsor: IDEAYA Biosciences

Sex: All

Age: 18+

Code: NCT07503808

Phase1, Recruiting

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A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

for
Neoplasms, Colorectal, Neoplasms
Location: Toronto, Montreal, Hamilton, Canton OH, Detroit MI,
Sponsor: GlaxoSmithKline

Sex: All

Age: 18+

Code: NCT07213609

Phase1, Phase2, Recruiting

A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

for
Advanced Breast Cancer, Metastatic Breast Cancer (HR+/ HER2-),
Location: New York NY, Long Island City NY, Grand Rapids MI,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07318805

Phase1, Recruiting

A Study of GSK5764227 in Combination With Standard of Care (SoC) or Other Agents in Participants With Advanced Solid Tumors

for
Neoplasms
Location: Lake Success NY
Sponsor: GlaxoSmithKline

Sex: All

Age: 18+

Code: NCT07277270

Phase1, Recruiting

A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors

for
SST2-positive Neuroendocrine Neoplasms, Neuroendocrine Tumors,
Location: New York NY, Philadelphia PA, Fairfax VA,
Sponsor: Crinetics Pharmaceuticals Inc.

Sex: All

Age: 18+

Code: NCT07129252

Phase1, Phase2, Recruiting

A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)

for
Neoplasm Malignant
Location: New Brunswick NJ, Montreal, Baltimore MD, Ottawa,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07209111

Phase2, Recruiting

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

for
HNSCC, ESCC, Esophageal Adenocarcinoma, Gastric Adenocarcinoma,
Location: Boston MA, New Haven CT, Hackensack NJ, Philadelphia PA,
Sponsor: Normunity AccelCo, Inc.

Sex: All

Age: 18+

Code: NCT07182149

Phase1, Recruiting

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

for
Diffuse Midline Glioma, H3 K27-Altered,
Location: Boston MA, Valhalla NY, New York NY, Philadelphia PA,
Sponsor: Children's Oncology Group

Sex: All

Age: 1 - 21

Code: NCT04870944

Phase1, Phase2, Recruiting

A First-in-Human Study of FID-022 in Solid Tumor Patients

for
Pancreatic Cancer, Cancer Cachexia
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT07249775

Recruiting

A Phase 1/2a, First-in-human, Study of BMS-986517 in Participants With Advanced Solid Tumors

for
Solid Tumours
Location: Pittsburgh PA, Sioux Falls SD, Fort Worth TX,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT07160725

Phase1, Phase2, Recruiting

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

for
Ovarian Neoplasms, Breast Neoplasms,
Location: Boston MA, New York NY, Philadelphia PA, Glen Burnie MD,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT07213791

Phase1, Recruiting

Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

for
Small Cell Lung Carcinoma,
Location: Boston MA, Montreal, Royal Oak MI, Iowa City IA,
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18 - 70+

Code: NCT07006727

Phase1, Recruiting

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

for
Non-Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer,
Location: Philadelphia PA, Minneapolis MN, Houston TX,
Sponsor: Fate Therapeutics

Sex: All

Age: 18+

Code: NCT07216105

Phase1, Recruiting

A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

for
Malignant Neoplasm
Location: Boston MA, Valhalla NY, New York NY, New Brunswick NJ,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 0 - 17

Code: NCT07630974

Phase1, Phase2, Recruiting

Clinical Study of MK-4884 in Participants With Advanced or Metastatic Solid Tumors (MK-4884-001)

for
Malignant Neoplasm
Location: Montreal, San Antonio TX
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07600749

Phase1, Recruiting

Study of [177Lu]Lu-DWJ155 and [68Ga]Ga-DWJ155 in Patients With Solid Tumors

for
Breast Cancer, Non-small Cell Lung Cancer (NSCLC),
Location: Montreal, Omaha NE
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07660055

Phase1, Recruiting