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A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors

for
Head and Neck Squamous Cell Carcinoma,
Location: Shreveport LA
Sponsor: Pure Biologics S.A.

Sex: All

Age: 18+

Code: NCT06700070

Early_phase1, Recruiting

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

for
Melanoma, Non-small Cell Lung Cancer,
Location: Fairfax VA, Pittsburgh PA, Grand Rapids MI, St Louis MO,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07115043

Phase1, Phase2, Recruiting

AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors

for
Vulvar Adenocarcinoma, PDAC - Pancreatic Ductal Adenocarcinoma,
Location: Fairfax VA, Grand Rapids MI, Irving TX
Sponsor: Avacta Life Sciences Ltd

Sex: All

Age: 18+

Code: NCT07454642

Phase1, Recruiting

A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.

for
PROC, Platinum Resistant Ovarian Cancer, Endometrial Cancer
Location: Long Island City NY, Philadelphia PA, Sarasota FL,
Sponsor: Whitehawk Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07470853

Phase1, Recruiting

Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors

for
Clinical Stage III Gastric Cancer AJCC v8,
Location: Houston TX
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06364410

Phase1, Recruiting

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IDOV-Immune for Advanced Solid Tumors

for
Colorectal Cancer, Pancreatic Cancer, Melanoma, Ovarian Cancer,
Location: St Louis MO, Houston TX, San Antonio TX
Sponsor: ViroMissile, Inc.

Sex: All

Age: 18+

Code: NCT06910657

Phase1, Recruiting

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

for
Endometrial Cancer, Cervical Cancer, Ovarian Cancer,
Location: Boston MA, Mineola NY, New York NY, East Brunswick NJ,
Sponsor: SystImmune Inc.

Sex: All

Age: 18+

Code: NCT06293898

Phase1, Recruiting

Study of Safety, Pharmacokinetic and Efficacy of APG-5918 in Advanced Solid Tumors or Lymphomas

for
Nasopharyngeal Carcinoma, Castrate Resistant Prostate Cancer,
Location: Springdale AR
Sponsor: Ascentage Pharma Group Inc.

Sex: All

Age: 18+

Code: NCT05415098

Phase1, Recruiting

A First-in-human, Phase I, Open-label, Multicenter Study of NM1F(Anti-PVRIG) in Patients With Advanced Solid Tumors

for
Ovarian Cancer, Melanoma, Triple Negative Breast Cancer,
Location: Fairfax VA, Dallas TX
Sponsor: Hefei TG ImmunoPharma Co., Ltd.

Sex: All

Age: 18+

Code: NCT05746897

Phase1, Recruiting

This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors

for
Non Small Cell Lung Cancer,
Location: Boston MA, Austin, TX 78758 TX, San Antonio TX
Sponsor: Zumutor Biologics Inc.

Sex: All

Age: 18+

Code: NCT06451497

Phase1, Recruiting

Modular Trial of sEphB4-HSA in EphrinB2-High Solid Tumors

for
Muscle-Invasive Bladder Carcinoma,
Location: Santa Monica CA
Sponsor: Vasgene Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06493552

Phase2, Phase3, Recruiting

A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors

for
Cancer, Melanoma Stage III, Melanoma Stage IV,
Location: New York NY, Morristown NJ, Weston FL, Pittsburgh PA,
Sponsor: Krystal Biotech, Inc.

Sex: All

Age: 18+

Code: NCT05970497

Phase1, Phase2, Recruiting

A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

for
Carcinoma, Non-small-Cell Lung
Location: Boston MA, Hackensack NJ, New Brunswick NJ,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT05498428

Phase2, Recruiting

A Study of NPX887 for Participants With Solid Tumors Known to Express B7-H7/HHLA2

for
Metastatic Malignant Neoplasm
Location: Boston MA, Bronx NY, Baltimore MD, Fairfax VA,
Sponsor: NextPoint Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06240728

Phase1, Recruiting

Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

for
Ewing Sarcoma, Colorectal Adenocarcinoma
Location: New York NY, Philadelphia PA, Fairfax VA,
Sponsor: Inhibrx Biosciences, Inc

Sex: All

Age: 12 - 70+

Code: NCT03715933

Phase1, Recruiting

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

for
Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer,
Location: Boston MA, New York NY, Fairfax VA, Pittsburgh PA,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT06128551

Phase1, Phase2, Recruiting

Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors

for
Advanced or Metastatic ER+ HER2- Breast Cancer (mBC),
Location: Boston MA, Sarasota FL, Grand Rapids MI, Nashville TN,
Sponsor: Olema Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT06784193

Phase1, Recruiting

A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation

for
KRAS P.G12C
Location: Sarasota FL, Detroit MI, Nashville TN, Houston TX,
Sponsor: D3 Bio (Wuxi) Co., Ltd

Sex: All

Age: 18+

Code: NCT05410145

Phase1, Phase2, Recruiting

Lead-212 PSV359 Therapy for Patients With Solid Tumors

for
Pancreatic Ductal Adenocarcinoma, Gastric Cancer,
Location: Miami FL, Pittsburgh PA, Columbus OH, Lexington KY,
Sponsor: Perspective Therapeutics

Sex: All

Age: 18 - 70+

Code: NCT06710756

Phase1, Phase2, Recruiting

A Study of JNJ-87704916, as Monotherapy and in Combination for Advanced Solid Tumors

for
Neoplasms
Location: New York NY, Montreal, Toronto, Pittsburgh PA,
Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All

Age: 18+

Code: NCT06311578

Phase1, Recruiting