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Safety and Efficacy of PIPAC Using Single Agent Mitomycin in Solid Tumors

for
Peritoneal Carcinomatosis
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT07487168

Phase1, Recruiting
New

Effects of Infusion Timing on Treatment Response in Solid Tumors

for
Lung Cancer, Non-small Cell Lung Cancer, Metastatic Lung Cancer,
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT07630168

Phase2, Recruiting

TT-4 and TT-10 as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors and Pleural Mesothelioma

for
Renal Cell Cancer, Castrate Resistant Prostate Cancer,
Location: Houston TX, Los Angeles CA
Sponsor: Portage Biotech

Sex: All

Age: 18+

Code: NCT04969315

Phase1, Phase2, Recruiting

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

for
Anatomic Stage III Breast Cancer AJCC v8,
Location: Boston MA, St Louis MO
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT07137416

Phase1, Recruiting

Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

for
Ovarian Cancer, Endometrial Cancer, Germ Cell Tumor,
Location: The Bronx NY, New York NY, Hackensack NJ,
Sponsor: Xencor, Inc.

Sex: All

Age: 15+

Code: NCT06276491

Phase1, Recruiting

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Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

for
Brain Cancer, Glioma
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT00870129

Recruiting

A Study of Navicixizumab Monotherapy or in Combination in Patients With Select Advanced Solid Tumors

for
Colorectal Cancer, Triple Negative Breast Cancer,
Location: New York NY, Tampa FL, Columbus OH, Atlanta GA,
Sponsor: OncXerna Theraputics, Inc.

Sex: All

Age: 18+

Code: NCT05453825

Phase2, Recruiting

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

for
Biliary Tract Cancer, Breast Cancer, Cervical Cancer,
Location: Boston MA, Miami FL, Denver CO, Nashville TN,
Sponsor: ModeX Therapeutics, An OPKO Health Company

Sex: All

Age: 18+

Code: NCT06239194

Phase1, Phase2, Recruiting

Phase 1, Safety and Tolerability Study of XmAb541 and XmAb808 in Advanced Solid Tumors

for
Ovarian Cancer
Location: The Bronx NY, New York NY, Fort Worth TX,
Sponsor: Xencor, Inc.

Sex: Female

Age: 18+

Code: NCT07593092

Phase1, Recruiting

A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors

for
Breast Cancer
Location: Rochester MN, Dallas TX, Vancouver, Stanford CA,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT05307705

Phase1, Recruiting

Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors

for
Pancreatic Ductal Adenocarcinoma, Non-Small Cell Lung Cancer,
Location: Montreal
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18 - 70+

Code: NCT07261631

Phase1, Recruiting

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

for
NSCLC (Advanced Non-small Cell Lung Cancer), HNSCC,
Location: Fairfax VA, Tampa FL, Farmington Hills MI,
Sponsor: ALX Oncology Inc.

Sex: All

Age: 18+

Code: NCT07085091

Phase1, Recruiting

A Study of Lorigerlimab in Participants With Advanced Solid Tumors

for
Platinum-resistant Ovarian Cancer,
Location: Montreal, Toronto, Pittsburgh PA, Grand Rapids MI,
Sponsor: MacroGenics

Sex: Female

Age: 18+

Code: NCT06730347

Phase2, Recruiting

A Study of Bi-Ligand-Drug Conjugate CBP-1019 in Patients With Advanced Solid Tumors

for
Cancer, Breast, Cancer, Lung, Cancer of Pancreas,
Location: Manhasset NY, Orlando FL, Cerritos CA
Sponsor: Coherent Biopharma (Hefei) Co., Ltd.

Sex: All

Age: 18+

Code: NCT05830097

Phase1, Phase2, Recruiting

A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors

for
Melanoma (Skin), Non Small Cell Lung Cancer, Breast Cancer
Location: Farmington Hills MI, Indianapolis IN, Dallas TX,
Sponsor: Hummingbird Bioscience

Sex: All

Age: 18+

Code: NCT06956690

Phase1, Phase2, Recruiting

Study of TBX-3400 in Subjects With Solid Malignant Tumors Resistant or Refractory to Standard Therapies

for
Cancer, Tumor, Solid, Refractory Cancer
Location: Los Angeles CA
Sponsor: Taiga Biotechnologies, Inc.

Sex: All

Age: 18+

Code: NCT04640246

Phase1, Phase2, Recruiting

Comparing the Efficacy of Endoscopic FNA vs FNB in Diagnosing Solid Gastrointestinal Lesions

for
Pancreatic Tumor, Gastric Tumor, Esophageal Tumor,
Location: Stony Brook NY
Sponsor: Stony Brook University

Sex: All

Age: 18+

Code: NCT01698190

Recruiting

A Modular Phase 1/2 Study With CT7439 in Participants With Solid Malignancies

for
Solid Malignancies
Location: Fairfax VA, Dallas TX, San Antonio TX
Sponsor: Carrick Therapeutics Limited

Sex: All

Age: 18+

Code: NCT06600789

Phase1, Phase2, Recruiting

A Phase 1 Study of IM-1021 in Participants With Advanced Cancer

for
Solid Malignancies, Hematologic Malignancies
Location: Providence RI, New Haven CT, Charlottesville VA,
Sponsor: Immunome, Inc.

Sex: All

Age: 18+

Code: NCT06823167

Phase1, Recruiting

A Phase 1 Study of 177Lu-IM-3050 in Participants With Advanced Cancer

for
Solid Malignancies
Location: Dothan AL, Houston TX, Palo Alto CA
Sponsor: Immunome, Inc.

Sex: All

Age: 18+

Code: NCT07505771

Phase1, Recruiting