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A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for
Non-small Cell Lung Cancer,
Location: Boston MA, New York NY, New Brunswick NJ, Pittsburgh PA,
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT05877599

Phase1, Recruiting

A Phase I First in Human Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of WGI-0301 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Baltimore MD, Whittier CA, Los Angeles CA
Sponsor: Zhejiang Haichang Biotech Co., Ltd.

Sex: All

Age: 18+

Code: NCT05267899

Phase1, Recruiting

A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPĪ±-CD47 Pathway, in Solid or Hematological Tumors

for
Advanced Solid Tumor, Refractory Non-Hodgkin Lymphoma
Location: Port Saint Lucie FL, Huntersville NC, Greenville SC,
Sponsor: FBD Biologics Limited

Sex: All

Age: 18+

Code: NCT05892718

Phase1, Recruiting

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

for
Locally Advanced Solid Tumors, Metastatic Solid Tumors
Location: Boston MA, Hollywood FL, Athens GA, Columbus OH,
Sponsor: Turning Point Therapeutics, Inc.

Sex: All

Age: 12+

Code: NCT03093116

Phase1, Phase2, Recruiting

Reduced Intensity Haploidentical BMT for High Risk Solid Tumors

for
Refractory and/or Relapsed Metastatic Solid Tumors
Location: Valhalla NY, The Bronx NY, Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 1 - 50

Code: NCT01804634

Phase2, Recruiting

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A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors

for
Clear Cell Renal Cell Carcinoma, Solid Tumors
Location: Boston MA, New York NY, Baltimore MD, Miami FL,
Sponsor: Arcus Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT05536141

Phase1, Recruiting

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

for
Advanced or Metastatic Solid Tumors, Breast Cancer,
Location: Boston MA, New Haven CT, New York NY, Philadelphia PA,
Sponsor: 858 Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06395519

Phase1, Phase2, Recruiting

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

for
Solid Tumor, Advanced Cancer, Metastatic Cancer, Gastric Cancer,
Location: Boston MA, New York NY, Madison WI, Aurora CO,
Sponsor: I-Mab Biopharma US Limited

Sex: All

Age: 18+

Code: NCT04900818

Phase1, Recruiting

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

for
Advanced Solid Tumor
Location: Boston MA, Montreal, Toronto, Pittsburgh PA, Tampa FL,
Sponsor: Senhwa Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT04890613

Phase1, Recruiting

Adapting for Latinx Populations an Intervention That Involves Discussing and Sharing Patients' Health-Related Values

for
Solid Tumor, Solid Tumor, Adult,
Location: The Bronx NY, New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 21+

Code: NCT04942717

Recruiting

A First-in-human Study of IBI343 in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors

for
Locally Advanced Unresectable or Metastatic Solid Tumors
Location: Irving TX, Austin TX, San Antonio TX
Sponsor: Innovent Biologics (Suzhou) Co. Ltd.

Sex: All

Age: 18+

Code: NCT05458219

Phase1, Recruiting

SMP-3124LP in Adults With Advanced Solid Tumors

for
Solid Tumor
Location: Celebration FL, Columbus OH, Nashville TN, Denver CO,
Sponsor: Sumitomo Pharma America, Inc.

Sex: All

Age: 18+

Code: NCT06526819

Phase1, Phase2, Recruiting

Study of the Safety and Efficacy of STI-6643 in Subjects With Advanced Solid Tumors

for
Solid Tumor, Relapsed Solid Neoplasm, Refractory Tumor
Location: Fairfax VA, Sioux Falls SD, Dallas TX
Sponsor: Sorrento Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT04900519

Phase1, Recruiting

A First-in-Human, Phase 1/2 Study of LAT010 in Patients with Advanced Solid Tumors (LIGHTSPEED-1)

for
Advanced Solid Tumor
Location: Margate FL
Sponsor: Latticon Antibody Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06277219

Phase1, Phase2, Recruiting

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

for
Advanced Solid Tumors, HER2 Mutation
Location: Boston MA, Toronto, Fort Myers FL, Cleveland OH,
Sponsor: Bayer

Sex: All

Age: 18+

Code: NCT06760819

Phase2, Recruiting

Study of GS-0201 Alone and in Combination in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Boston MA, New York NY, Houston TX, Irving TX,
Sponsor: Gilead Sciences

Sex: All

Age: 18+

Code: NCT06167317

Phase1, Recruiting

Evaluation of the Efficacy and Safety of [18F]-ML-10, as a PET Imaging Radiotracer, in Early Detection of Response of Brain Metastases of Solid Tumors to Radiation Therapy.

for
Brain Metastases, Solid Tumors
Location: Boston MA, New York city NY, Pittsburgh PA
Sponsor: Aposense Ltd.

Sex: All

Age: 18+

Code: NCT00805636

Phase2, Recruiting

A Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors

for
Solid Tumor
Location: Boston MA, Fairfax VA, Grand Rapids MI, San Antonio TX,
Sponsor: PAQ Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06797336

Phase1, Recruiting

A Study of D3L-001 as Monotherapy in Subjects With HER2-Positive Advanced Solid Tumors

for
HER-2 Positive Advanced Solid Tumors
Location: New York NY
Sponsor: D3 Bio (Wuxi) Co., Ltd

Sex: All

Age: 18+

Code: NCT05957536

Phase1, Recruiting

Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophosphamide in Recurrent or Refractory Pediatric Solid Tumors

for
Recurrent or Refractory Solid Tumors, Ewing Sarcoma,
Location: Cincinnati OH, Milwaukee WI, Houston TX, Dallas TX,
Sponsor: South Plains Oncology Consortium

Sex: All

Age: 1 - 20

Code: NCT02013336

Phase1, Recruiting