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Active & Responsive

Safety Trial of Antimicrobial Therapy and Precision Radiation Therapy in Patients With Oligoprogressive Non-small Cell Lung Cancer

for
Early Stage Non-Small Cell Lung Cancer
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 18+

Code: NCT03546829

Phase 1, Recruiting
Active & Responsive

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

for
Non-Small Cell Lung Cancer
Location: Baltimore MD, Fairfax VA, Columbus OH, Lexington KY,
Sponsor: BioNTech SE

Sex: All

Age: 18+

Code: NCT05142189

Phase 1, Recruiting
Active & Responsive

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Boston MA, Atlanta GA, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18 - 70+

Code: NCT06059391

Phase 2, Recruiting
Active & Responsive

Early Prediction of Oral Cancer by S100A7 Immunohistochemistry Signature-based Assessment

for
Oral Neoplasm
Location: London, Edmonton
Sponsor: Proteocyte Diagnostics Inc.

Sex: All

Age: 15 - 70+

Code: NCT04622462

Recruiting
Active & Responsive

The Cancer of the Pancreas Screening-5 CAPS5)Study

for
Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation,
Location: Boston MA, New Haven CT, New York NY, Philadelphia PA,
Sponsor: Johns Hopkins University

Sex: All

Age: 18+

Code: NCT02000089

Phase 3, Recruiting

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Active & Responsive

Cabozantinib in Combination With Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Cancer

for
Infiltrating Bladder Urothelial Carcinoma With Squamous Differentiation,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT04878029

Phase 1, Recruiting
Active & Responsive

Screening Women With Prior HPV for Anal Neoplasia

for
HPV-related Lower Genital Tract Neoplasias,
Location: New York NY, Charleston SC, Houston TX
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: Female

Age: 35+

Code: NCT05217940

Recruiting
Active & Responsive

Oxaliplatin and Liposomal Irinotecan (Plus Trastuzumab for HER2-positive Disease) in Advanced Esophageal and Gastric Adenocarcinoma

for
Esophageal Adenocarcinoma, Gastric Adenocarcinoma
Location: Madison WI
Sponsor: University of Wisconsin, Madison

Sex: All

Age: 18+

Code: NCT04150640

Phase 2, Recruiting
Active & Responsive

Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy

for
Lymphoid Leukemia
Location: Boston MA, The Bronx NY, New Castle DE, Baltimore MD,
Sponsor: Stanford University

Sex: All

Age: 0 - 26

Code: NCT05865301

Recruiting
Active & Responsive

Study of 18F-FFNP Breast PET/MRI

for
Breast Cancer
Location: Madison WI
Sponsor: University of Wisconsin, Madison

Sex: Female

Age: 18+

Code: NCT06086704

Phase 2, Recruiting
Active & Responsive

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

for
Esophageal Squamous Cell Carcinoma
Location: East Syracuse NY, Pittsburgh PA, Tucson AZ,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT05319730

Phase 1, Phase 2, Recruiting
Active & Responsive

Quebec Pancreas Cancer Study

for
Pancreas Cancer, Pancreatic Cancer, Pancreas Neoplasm,
Location: Montreal
Sponsor: George Zogopoulos

Sex: All

Age: 18+

Code: NCT04104230

Recruiting
Active & Responsive

Predicting Response to Neoadjuvant Endocrine Therapy (Neo-PREDICT)

for
Breast Cancer Stage I, Breast Cancer Stage II,
Location: Washington D.C. DC
Sponsor: George Washington University

Sex: All

Age: 21+

Code: NCT06806930

Phase 2, Recruiting
Active & Responsive

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

for
Carcinoma, Non-Small-Cell Lung
Location: Halifax, Boston MA, Norwich CT, New Haven CT, Quebec,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06623422

Phase 3, Recruiting
Active & Responsive

Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research

for
Malignant Central Nervous System Neoplasm
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06117930

Recruiting
Active & Responsive

Sirolimus in Combination With Metronomic Chemotherapy in Children With High-Risk Solid Tumors

for
Solid Tumor
Location: Pittsburgh PA, Atlanta GA, St Louis MO, Houston TX
Sponsor: Emory University

Sex: All

Age: 1 - 30

Code: NCT04469530

Phase 2, Recruiting
Active & Responsive

Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders

for
Neurodevelopmental Disorders, Autism, Autism Spectrum Disorder,
Location: Kingston, Toronto, Hamilton, London, Edmonton, Calgary
Sponsor: Holland Bloorview Kids Rehabilitation Hospital

Sex: All

Age: 8 - 17

Code: NCT06081348

Phase 2, Recruiting
Active & Responsive

Nivolumab Alone or Plus Relatlimab or Ipilimumab for Patients With Locally-Advanced Unresectable or Metastatic Basal Cell Carcinoma

for
Basal Cell Carcinoma
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT03521830

Phase 2, Recruiting
Active & Responsive

Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung Cancer

for
Advanced Lung Adenocarcinoma, Refractory Lung Adenocarcinoma,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT06495125

Phase 2, Recruiting
Active & Responsive

Acolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer

for
Breast Atypical Hyperplasia, Breast Carcinoma,
Location: Columbus OH, Chicago IL, Kansas City KS, Duarte CA
Sponsor: National Cancer Institute (NCI)

Sex: Female

Age: 35+

Code: NCT05941520

Phase 2, Recruiting