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Dose Escalation and Expansion Study of BH3120 Alone or With Pembrolizuamb in Advanced or Metastatic Solid Tumors

for
Advanced or Metastatic Solid Tumors
Location: Tampa FL, Cincinnati OH, Grand Rapids MI,
Sponsor: Hanmi Pharmaceutical Company Limited

Sex: All

Age: 18+

Code: NCT06234397

Phase 1, Recruiting

A First-in-Human (FIH) Study of BG-C137, an Anti-Fibroblast Growth Factor Receptor 2b (FGFR2b) Antibody Drug Conjugate, in Participants With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: New Haven CT, Madison WI, Houston TX, Seattle WA,
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT06625593

Phase 1, Recruiting

Study of ON 123300 in Patients With Advanced Cancer

for
Solid Tumors, Adult
Location: Greenville SC, Grand Rapids MI, Dallas TX
Sponsor: Traws Pharma, Inc.

Sex: All

Age: 18+

Code: NCT04739293

Phase 1, Recruiting

First in Human Study of TORL-1-23 in Participants With Advanced Cancer

for
Advanced Solid Tumor, Ovarian Cancer, Endometrial Cancer, NSCLC
Location: New York NY, Fairfax VA, Cleveland OH, Lexington KY,
Sponsor: TORL Biotherapeutics, LLC

Sex: All

Age: 18+

Code: NCT05103683

Phase 1, Recruiting

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

for
Oncology, MEK Mutation, RAF Gene Mutation,
Location: New York NY, Fairfax VA, Buffalo NY, Pittsburgh PA,
Sponsor: Nested Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06326411

Phase 1, Recruiting

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Dose-Escalation and Expansion Trial of NC-6300 in Patients With Advanced Solid Tumors or Soft Tissue Sarcoma

for
Solid Tumor, Soft Tissue Sarcoma, Metastatic Sarcoma, Sarcoma
Location: Durham NC, Chapel Hill NC, Santa Monica CA
Sponsor: NanoCarrier Co., Ltd.

Sex: All

Age: 18 - 70+

Code: NCT03168061

Phase 1, Phase 2, Recruiting

A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)

for
Metastatic Solid Tumor, Brain Metastases
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05673928

Phase 2, Recruiting

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

for
MTAP-deleted Solid Tumors
Location: Boston MA, New York NY, Orlando FL, Grand Rapids MI,
Sponsor: Bayer

Sex: All

Age: 18+

Code: NCT06914128

Phase 1, Phase 2, Recruiting

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas

for
Solid Tumor, Sarcoma, Leiomyosarcoma,
Location: Boston MA, Lake Success NY, Fairfax VA, Cleveland OH,
Sponsor: STORM Therapeutics LTD

Sex: All

Age: 18+

Code: NCT06975293

Phase 1, Phase 2, Recruiting

Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

for
Metastatic Hepatocellular Carcinoma, Solid Tumors,
Location: Boston MA, New York NY, Baltimore MD, Toronto,
Sponsor: Tyra Biosciences, Inc

Sex: All

Age: 18+

Code: NCT06915753

Phase 1, Recruiting

A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

for
Solid Tumor, Adult
Location: Los Angeles CA
Sponsor: BioInvent International AB

Sex: All

Age: 18+

Code: NCT04219254

Phase 1, Phase 2, Recruiting

A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

for
Locally Advanced Solid Tumor, Metastatic Solid Tumor
Location: Boston MA, New York NY, Baltimore MD,
Sponsor: Nuvalent Inc.

Sex: All

Age: 18+

Code: NCT06521554

Phase 1, Recruiting

Study of AVZO-021 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor, HR+/HER2- Breast Cancer,
Location: Mineola NY, New York NY, Sarasota FL, Portland OR,
Sponsor: Avenzo Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05867251

Phase 1, Phase 2, Recruiting

A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK061 in Patients With Advanced Solid Tumors

for
Solid Tumor
Location: Dallas TX
Sponsor: Abbisko Therapeutics Co, Ltd

Sex: All

Age: 18+

Code: NCT05244551

Phase 1, Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors, Colorectal Cancer
Location: New Brunswick NJ, Toronto, Atlanta GA, Ann Arbor MI,
Sponsor: Vividion Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06004245

Phase 1, Recruiting

A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer

for
Solid Tumor, Epithelial Ovarian Cancer, Fallopian Tube Cancer,
Location: Boston MA, Providence RI, New York NY, Durham NC,
Sponsor: K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Sex: Female

Age: 18+

Code: NCT04516447

Phase 1, Recruiting

Study to Evaluate Maximum Tolerated Dose of Oral CB-03-10 With Dose Expansion Phase, in Advanced Solid Tumors

for
Advanced Refractory Solid Tumors,
Location: New Haven CT, Ohio City OH, Michigan Center MI,
Sponsor: Cosmo Technologies Ltd

Sex: All

Age: 18+

Code: NCT03863145

Early Phase 1, Recruiting

QTX3034 in Patients With KRAS G12D Mutation

for
Solid Tumors
Location: New Haven CT, The Bronx NY, New York NY, Fairfax VA,
Sponsor: Quanta Therapeutics

Sex: All

Age: 18+

Code: NCT06227377

Phase 1, Recruiting

A Study of Codrituzumab in Children and Young Adults With Solid Tumors and Have Not Responded to Treatment or Have Come Back After Treatment

for
Primary Extra-cranial Solid Tumor,
Location: Boston MA, New York NY, Atlanta GA, Cincinnati OH,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 1 - 21

Code: NCT04928677

Phase 1, Recruiting

Determine Safety & Recommended Phase 2 Dosing of Zeaxanthin Alone or in Combination w/Pembrolizumab in Patients With Metastatic Cancer

for
Cancer Metastatic, Metastatic Solid Tumor
Location: Paramus NJ
Sponsor: Valley Health System

Sex: All

Age: 18 - 70+

Code: NCT05232409

Phase 1, Recruiting