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Active & Responsive

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

for
Recurrent Head and Neck Squamous Cell Carcinoma,
Location: Boston MA, Waterford CT, New Haven CT, Stony Brook NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT04671667

Phase 2, Recruiting
Active & Responsive

KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis

for
Myasthenia Gravis, Generalized Myasthenia Gravis
Location: Philadelphia PA, Miami FL, Indianapolis IN, Columbia MO,
Sponsor: Kyverna Therapeutics

Sex: All

Age: 18 - 70+

Code: NCT06193889

Phase 2, Phase 3, Recruiting
Active & Responsive

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

for
Metastatic Head and Neck Squamous Cell Carcinoma,
Location: Boston MA, Saint Johnsbury VT, Lebanon NH, Commack NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06589804

Phase 3, Recruiting
Active & Responsive

Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for
Anatomic Stage I Breast Cancer AJCC v8,
Location: Gloucester MA, Beverly MA, Peabody MA, Winchester MA,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT05929768

Phase 3, Recruiting
Active & Responsive

Prospective Study of Intensity-Modulated Proton Therapy (IMPT) for Small Cell Lung Cancer

for
Small-cell Lung Cancer
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT04342429

Recruiting

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Active & Responsive

JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer

for
Non-Small Cell Lung Cancer
Location: Neptune City NJ, Montreal, Syracuse NY, Ottawa, Toronto,
Sponsor: University of Texas Southwestern Medical Center

Sex: All

Age: 18+

Code: NCT02468024

Phase 3, Recruiting
Active & Responsive

Community Services Navigation to Advance Health Equity in Breast Cancer Screening

for
Breast Cancer
Location: Salt Lake City UT
Sponsor: University of Utah

Sex: All

Age: 18+

Code: NCT06305312

Recruiting
Active & Responsive

Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)

for
Generalized Myasthenia Gravis
Location: Boston MA, New Haven CT, New Hyde Park NY,
Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT04202341

Recruiting
Active & Responsive

Intraoperative OCT Guidance of Intraocular Surgery II

for
Macular Holes, Epiretinal Membrane, Diabetic Retinopathy,
Location: Durham NC
Sponsor: Duke University

Sex: All

Age: 0+

Code: NCT03713268

Recruiting
Active & Responsive

ILKN421H Plus Pembrolizumab in Advanced Non-Small Cell Lung Cancer

for
Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC),
Location: Fort Worth TX, Los Angeles CA
Sponsor: iLeukon Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07452224

Phase 2, Recruiting
Active & Responsive

GUCY2C Prime-Boost Vaccination for Advanced Colorectal and Small Bowel Adenocarcinomas

for
Colorectal Cancer, Small Bowel Adenocarcinoma
Location: Philadelphia PA
Sponsor: Thomas Jefferson University

Sex: All

Age: 18+

Code: NCT07417488

Phase 1, Recruiting
Active & Responsive

Testing a Web-based Intervention for Radioactive Iodine Symptom Management to Improve Health-related Quality of Life Among Differentiated Thyroid Cancer Patients

for
Thyroid Neoplasms
Location: Washington D.C. DC
Sponsor: Georgetown University

Sex: All

Age: 18+

Code: NCT06853925

Recruiting
Active & Responsive

Evaluation of the Clinical and Psychological Impact of Vitamin D Replacement in Adolescent Females at Risk for Polycystic Ovarian Syndrome (PCOS)

for
Polycystic Ovarian Syndrome in Adolescent Females,
Location: New Haven CT
Sponsor: Yale University

Sex: Female

Age: 13 - 21

Code: NCT04355572

Recruiting
Active & Responsive

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

for
Triple Negative Breast Neoplasms
Location: Quebec, Chicoutimi, Mineola NY, New York NY,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06841354

Phase 3, Recruiting
Active & Responsive

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

for
Platinum-resistant Ovarian Cancer,
Location: Stony Brook NY, Greenville NC, Silver Spring MD,
Sponsor: Genelux Corporation

Sex: Female

Age: 18+

Code: NCT05281471

Phase 3, Recruiting
Active & Responsive

StableEyes With Active Neurofeedback

for
Vestibular Disorder, Vestibular Schwannoma,
Location: Baltimore MD
Sponsor: Johns Hopkins University

Sex: All

Age: 21 - 70

Code: NCT05622344

Recruiting
Active & Responsive

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

for
Colorectal Cancer Stage II, Colorectal Cancer Stage III
Location: Rockport ME, Belfast ME, Damariscotta ME, Augusta ME,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT07018869

Phase 3, Recruiting
Active & Responsive

Building Connections

for
Cancer Colorectal, Cancer Cervix, Depression, Anxiety, Obesity
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18 - 70+

Code: NCT07091032

Recruiting
Active & Responsive

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

for
Plasma Cell Myeloma
Location: Exeter NH, Westerly RI, Waterford CT, Guilford CT,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 0+

Code: NCT05561387

Phase 3, Recruiting
Active & Responsive

Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)

for
Brain Tumor, Recurrent, Brain Tumor, Brain Tumor, Primary,
Location: Boston MA, Providence RI, Valhalla NY, The Bronx NY,
Sponsor: GT Medical Technologies, Inc.

Sex: All

Age: 0+

Code: NCT04427384

Recruiting