Recruiting

Low Blood Sugar

Sponsor:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Code:

NCT00001276

Conditions

Hypoglycemia

Insulinoma

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Hypoglycemia is the term used to refer to lower than normal levels of blood sugar. This study will continue to research the causes of hypoglycemia.

Patients involved in the study will be admitted to the Clinical Center of the National Institutes of Health and undergo tests for evaluating blood sugar. Patients will be required to refrain from eating for a set period of time and will undergo blood tests for insulin levels and several other specific diagnostic tests related to insulin secretion. The patients will be under supervision and will be provided with appropriate medical and surgical attention as needed....

Conditions

Hypoglycemia

Insulinoma

Study ID

NCT00001276

Start date

May 21, 1991

Status verified date

Aug 18, 2026

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

  • INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Male, females ages >= 18.
2. Patients with documented fasting blood glucose below 55 mg/dl.

4\. Patients with biochemical evidence for insulinoma or other pancreatic neuroendocrine tumors.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. Patients with significant cardiac disease will be excluded.
2. Subjects who are pregnant per self-report.
3. Medically unstable per the assessment of the PI.

Study Design

Enrollment

1500 participants

Anticipated

Interventions and Outcome Measures

Arms

Patients with hypoglycemia

Patients with hypoglycemia due to diverse etiologies.

Primary outcome measure

  • Treatment Outcomes [ Time Frame: every 1-3 months ]

Central Contacts and Locations

Central contacts

Craig S Cochran, R.N.

(301) 402-1880craigc@bdg10.niddk.nih.gov

Ranganath Muniyappa, M.D.

(301) 451-7702muniyapr@mail.nih.gov

Locations

National Institutes of Health Clinical Center

Recruiting

Bethesda, Maryland, United States, 20892

More Information

Sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Last update posted

Sep 8, 2026

Last verified

Aug 18, 2026

Keywords

  • Hypoglycemia
  • Insulinoma
  • Natural History

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) on 2026-09-08.