Recruiting

Observational Study

Sponsor:

National Institute of Mental Health (NIMH)

Code:

NCT00001360

Conditions

Healthy Volunteer

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Study Details

Brief summary:

The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks.

This study will use functional magnetic resonance imaging (fMRI) to examine blood flow to areas of the brain as participants engage in tasks associated with visual perception, visual recognition, and memory....

Conditions

Healthy Volunteer

Study ID

NCT00001360

Start date

Sep 17, 1993

Status verified date

Aug 19, 2026

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

  • INCLUSION CRITERIA:
  • Healthy adults, with at least a high school education, aged 18 to 65 years, will be recruited to participate in the study.
  • Able to read and write in English to guarantee understanding of all written and spoken instructions, which are in English.

EXCLUSION CRITERIA:

Subjects will be excluded if they:

  • have evidence of, or a history of:
  • major medical, neurological or psychiatric illness
  • serious head injury
  • learning disability-drug or alcohol abuse or dependence in the past 3 months, except nicotine

-are taking prescription drugs or supplements that may affect brain function-

-have serious vision or hearing problems

In addition to the above, additional exclusion criteria apply for all MRI studies:

  • Female subjects who are pregnant or have a positive pregnancy test 24 hours prior to an experiment will be excluded from neuroimaging studies.
  • All subjects will be questioned prior to MRI scanning for possible occupational exposure to metal slivers or shavings, which may have become accidentally lodged in the tissues of the head or neck. Subjects with surgical clips or shrapnel in or near the brain or blood vessels, subjects with cochlear implants, subjects with any metallic body in the eye or CNS, and subjects with any form of implant wire or metal device which may concentrate radiofrequency fields will be excluded from MRI scanning experiments because of possible risks during MRI scanning. Those whose history is suggestive of such a problem will also be excluded from the MRI portion of the experiments. They may still participate in the behavioral and MEG experiments.
  • Subjects unable to lie flat on their back for up to 3 hours may not be eligible to participate in MRI scans.

Study Design

Enrollment

4100 participants

Anticipated

Interventions and Outcome Measures

Arms

1

Normal volunteer participants aged 18-65 who are in good general health.

Primary outcome measure

  • Cognitive tasks and neuroimaging. [ Time Frame: ongoing ]

Central Contacts and Locations

Central contacts

NIMH LBC Volunteer

(301) 827-5157nimhlbcvolunteer@mail.nih.gov

Christopher I Baker, Ph.D.

(301) 435-6058bakerchris@mail.nih.gov

Locations

National Institutes of Health Clinical Center

Recruiting

Bethesda, Maryland, United States, 20892

Contacts

NIH Clinical Center Office of Patient Recruitment (OPR)

800-411-1222ccopr@nih.gov

More Information

Sponsor

National Institute of Mental Health (NIMH)

Last update posted

Sep 1, 2026

Last verified

Aug 19, 2026

Keywords

  • Cognition
  • Vision
  • Cortex
  • Visual Processing
  • Magnetic Resonance Imaging
  • Natural History

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by National Institute of Mental Health (NIMH) on 2026-09-01.