Recruiting

Observational Study

Sponsor:

National Cancer Institute (NCI)

Code:

NCT00001823

Conditions

Synovial Cell Cancer

Melanoma

Colorectal Cancer

Lung Cancer

Bladder Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Background:

The National Cancer Institute Surgery Branch (NCI-SB) has developed experimental therapies that involve taking white blood cells from patients' tumor or from their blood, growing them in the laboratory in large numbers, and then giving the cells back to the patient.

Objective:

This study will allow patients to under screening and evaluation for participation in NC-SB Protocols.

Eligibility:

Patients 18 years or older must meet the minimum eligibility criteria for an NCI-SB treatment protocol.

Design

Patients will undergo testing and evaluations as required by the appropriate NCI-SB treatment protocol.

Conditions

Synovial Cell Cancer

Melanoma

Colorectal Cancer

Lung Cancer

Bladder Cancer

Study ID

NCT00001823

Start date

Jul 11, 1999

Status verified date

Aug 5, 2026

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

  • INCLUSION CRITERIA:

Age >= 18 years.

Patient suspected of having, or with biopsy proven, malignant disease.

Patient is able to understand and willing to sign a written informed consent document.

Patient is being evaluated for treatment on an NCI-SB protocols.

EXCLUSION CRITERIA:

Women of child-bearing potential who are pregnant or plan to become pregnant because of the potentially dangerous effects of some of the screening procedures (e.g., nuclear medicine or other imaging scans) on the fetus.

Study Design

Enrollment

7000 participants

Anticipated

Interventions and Outcome Measures

Arms

A/Surgery Branch Protocol Candidates

Patients suspected of having, or with biopsy proven, malignant disease being evaluated for or treated on NCI Surgery Branch protocols

Primary outcome measure

  • Number of individuals suitable for NCI Surgery Branch clinical research protocols [ Time Frame: 25 Years ]
  • Frequency of HLA type, gene specific mutations, or expression of neoantigens in malignant tumors [ Time Frame: 25 years ]
  • Results of screening tests [ Time Frame: 25 years ]

Central Contacts and Locations

Central contacts

NCI SB Immunotherapy Recruitment Center

(866) 820-4505irc@nih.gov

Locations

National Institutes of Health Clinical Center

Recruiting

Bethesda, Maryland, United States, 20892

Contacts

For more information at the NIH Clinical Center contact National Cancer Institute Referral Office

888-624-1937

More Information

Sponsor

National Cancer Institute (NCI)

Last update posted

Sep 8, 2026

Last verified

Aug 5, 2026

Keywords

  • Cancer
  • Gene Therapy
  • Immunotherapy
  • Clinical Trial

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by National Cancer Institute (NCI) on 2026-09-08.