Recruiting
Phase 1

Photodynamic Therapy

Sponsor:

Medical College of Wisconsin

Code:

NCT00002647

Conditions

Brain and Central Nervous System Tumors

Metastatic Cancer

Eligibility Criteria

Sex: All

Age: 3 - 70

Healthy Volunteers: Not accepted

Interventions

verteporfin

conventional surgery

Study Details

Brief summary:

RATIONALE: Photodynamic therapy uses light and photosensitizing drugs to kill tumor cells and may be an effective treatment for refractory brain tumors.

PURPOSE: This phase I trial is studying the side effects and best dose of photodynamic therapy using porfimer sodium in treating patients with refractory brain tumors, including astrocytoma, ependymoma, and medulloblastoma.

Conditions

Brain and Central Nervous System Tumors

Metastatic Cancer

Study ID

NCT00002647

Start date

May, 1994

Status verified date

Jun, 2009

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 3 - 70

Healthy Volunteers: Not accepted

DISEASE CHARACTERISTICS:

  • Diagnosis of supratentorial or infratentorial brain tumor

  • Localized, non-disseminated
  • Primary tumor or solitary metastasis
  • Recurrent or progressive
  • Unresectable
  • Negative CSF
  • Must have failed standard therapy including radiotherapy
  • Measurable disease as evidenced by CT scan or MRI

  • Single or multiple masses accessible to light administration

PATIENT CHARACTERISTICS:

Age:

  • 3 to 70

Performance status:

  • Not specified

Life expectancy:

  • At least 2 months

Hematopoietic:

  • Absolute neutrophil count at least 1,000/mm3
  • May transfuse platelets

Hepatic:

  • PT and PTT normal

Renal:

  • Not specified

Other:

  • Not pregnant

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • Not specified

Chemotherapy:

  • At least 6 weeks since prior chemotherapy

Endocrine therapy:

  • Not specified

Radiotherapy:

  • See Disease Characteristics
  • No prior brachytherapy

Surgery:

  • See Disease Characteristics

Other:

  • No other concurrent antitumor therapy

Study Design

Enrollment

24 participants

Anticipated

Primary purpose

Treatment

Interventions and Outcome Measures

Interventions

verteporfin

conventional surgery

Central Contacts and Locations

Locations

Medical College of Wisconsin Cancer Center

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Clinical Trials Office - Medical College of Wisconsin Cancer C

414-805-4380

Midwest Children's Cancer Center at Children's Hospital of Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Bruce A. Kaufman, MD

414-266-2000

More Information

Sponsor

Medical College of Wisconsin

Last update posted

Sep 20, 2013

Last verified

Jun, 2009

Keywords

  • recurrent adult brain tumor
  • tumors metastatic to brain
  • recurrent childhood brain stem glioma
  • recurrent childhood anaplastic astrocytoma
  • recurrent childhood anaplastic oligoastrocytoma
  • recurrent childhood anaplastic oligodendroglioma
  • recurrent childhood cerebellar astrocytoma
  • recurrent childhood cerebral astrocytoma
  • recurrent childhood diffuse astrocytoma
  • recurrent childhood fibrillary astrocytoma
  • recurrent childhood gemistocytic astrocytoma
  • recurrent childhood giant cell glioblastoma
  • recurrent childhood glioblastoma
  • recurrent childhood gliomatosis cerebri
  • recurrent childhood gliosarcoma
  • recurrent childhood oligodendroglioma
  • recurrent childhood pilocytic astrocytoma
  • recurrent childhood pilomyxoid astrocytoma
  • recurrent childhood pleomorphic xanthoastrocytoma
  • recurrent childhood protoplasmic astrocytoma
  • recurrent childhood subependymal giant cell astrocytoma
  • recurrent childhood visual pathway and hypothalamic glioma
  • recurrent childhood visual pathway glioma
  • recurrent childhood pineoblastoma
  • recurrent childhood supratentorial primitive neuroectodermal tumor
  • recurrent childhood medulloblastoma
  • recurrent childhood ependymoma
  • recurrent childhood brain tumor
  • adult anaplastic astrocytoma
  • adult anaplastic ependymoma
  • adult anaplastic meningioma
  • adult anaplastic oligodendroglioma
  • adult brain stem glioma
  • adult central nervous system germ cell tumor
  • adult choroid plexus tumor
  • adult craniopharyngioma
  • adult diffuse astrocytoma
  • adult ependymoblastoma
  • adult ependymoma
  • adult giant cell glioblastoma
  • adult glioblastoma
  • adult gliosarcoma
  • adult medulloblastoma
  • meningeal melanocytoma
  • adult meningeal hemangiopericytoma
  • adult oligodendroglioma
  • adult papillary meningioma
  • adult pilocytic astrocytoma
  • adult pineal gland astrocytoma
  • adult pineoblastoma
  • adult pineocytoma
  • adult subependymal giant cell astrocytoma
  • adult subependymoma
  • adult supratentorial primitive neuroectodermal tumor (PNET)
  • childhood grade I meningioma
  • childhood grade II meningioma
  • childhood grade III meningioma
  • adult grade III meningioma
  • childhood central nervous system germ cell tumor
  • childhood choroid plexus tumor
  • childhood craniopharyngioma
  • childhood infratentorial ependymoma
  • childhood supratentorial ependymoma
  • childhood low-grade cerebral astrocytoma
  • childhood high-grade cerebral astrocytoma

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Medical College of Wisconsin on 2013-09-20.