Recruiting
Phase 1

Phosphorus 32

Sponsor:

Center for Molecular Medicine

Code:

NCT00004129

Conditions

Brain and Central Nervous System Tumors

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

brachytherapy

phosphorus P32

Study Details

Brief summary:

RATIONALE: Radioactive drugs such as phosphorus 32 may be able to kill tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of phosphorus 32 in treating patients with glioblastoma multiforme.

Conditions

Brain and Central Nervous System Tumors

Study ID

NCT00004129

Start date

Sep, 1999

Status verified date

Apr, 2008

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

DISEASE CHARACTERISTICS:

  • Histologically proven grade 4 astrocytoma (glioblastoma)

  • Failed external beam radiotherapy and/or surgery OR
  • Poor prognosis disease
  • No clinical evidence of metastatic disease within the CNS other than the primary tumor site
  • Stereotactic biopsy or gross total excision with residual tumor
  • Lesion 3 to 5 cm in size
  • No spinal cord tumor(s)

PATIENT CHARACTERISTICS:

Age:

  • 18 and over

Performance status:

  • Karnofsky 70-100%

Life expectancy:

  • Not specified

Hematopoietic:

  • WBC at least 3,000/mm3
  • Neutrophil count at least 1,900/mm3
  • Platelet count at least 100,000/mm3
  • Hemoglobin at least 9 g/dL (transfusion allowed)

Hepatic:

  • Not specified

Renal:

  • Creatinine no greater than 1.5 mg/dL
  • BUN less than 25 mg/dL

Other:

  • Not pregnant
  • Negative pregnancy test
  • Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • Not specified

Chemotherapy:

  • Not specified

Endocrine therapy:

  • Not specified

Radiotherapy:

  • See Disease Characteristics

Surgery:

  • See Disease Characteristics

Study Design

Enrollment

12 participants

Anticipated

Primary purpose

Treatment

Interventions and Outcome Measures

Interventions

brachytherapy

phosphorus P32

Central Contacts and Locations

Locations

Center for Molecular Medicine

Recruiting

Garden City, New York, United States, 11530

Contacts

Stanley E. Order, MD, ScD, FACR

516-222-5190

More Information

Sponsor

Center for Molecular Medicine

Last update posted

Sep 17, 2013

Last verified

Apr, 2008

Keywords

  • recurrent adult brain tumor
  • adult glioblastoma
  • adult giant cell glioblastoma
  • adult gliosarcoma

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Center for Molecular Medicine on 2013-09-17.