Recruiting

Depression, Peptides, Steroids

Sponsor:

National Center for Research Resources (NCRR)

Code:

NCT00004334

Conditions

Cushing's Syndrome

Eligibility Criteria

Sex: All

Age: 20 - 60

Healthy Volunteers: Not accepted

Study Details

Brief summary:

OBJECTIVES: I. Study the relationship between dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and disorders of mood, vegetative function, and cognition in patients with Cushing's disease.

II. Identify subgroups of patients with Cushing's disease who differ in the presence and severity of the depressive syndrome, and uncover HPA axis dysregulation differences among them using corticotropin-releasing hormone, metyrapone, and dexamethasone challenge testing.

Conditions

Cushing's Syndrome

Study ID

NCT00004334

Start date

Jul, 1994

Status verified date

Dec, 2003

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 20 - 60

Healthy Volunteers: Not accepted

PROTOCOL ENTRY CRITERIA:

  • Patients aged 20 to 60 with spontaneous active Cushing's syndrome
  • At least 2 weeks since medication with psychoactive effects or influence on cortisol metabolism by hepatic hydroxylating enzyme induction
  • Antihypertensives allowed for severe hypertension
  • No barbiturates
  • No phenytoin

Study Design

Enrollment

8 participants

Interventions and Outcome Measures

Central Contacts and Locations

Locations

University of Michigan Health Systems

Recruiting

Ann Arbor, Michigan, United States, 48109

Contacts

Monica N. Starkman

313-764-6168

More Information

Sponsor

National Center for Research Resources (NCRR)

Last update posted

Jun 24, 2005

Last verified

Dec, 2003

Keywords

  • Cushing's syndrome
  • endocrine disorders
  • rare disease

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-05. This information was provided to ClinicalTrials.gov by National Center for Research Resources (NCRR) on 2005-06-24. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.