Recruiting
Phase 2

Lovastatin, Chenodeoxycholic Acid, Diet

Sponsor:

National Center for Research Resources (NCRR)

Code:

NCT00004346

Conditions

Cerebrotendinous Xanthomatosis

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

chenodeoxycholic acid

lovastatin

Study Details

Brief summary:

OBJECTIVES: I. Assess the biosynthesis of cholesterol and cholestanol, and measure the turnover of individual sterols and bile acids in patients with cerebrotendinous xanthomatosis before and after a cholesterol- and cholestanol-free diet.

II. Assess the biosynthesis of cholesterol and cholestanol, and measure the turnover of individual sterols and bile acids in these patients before and after lovastatin and chenodeoxycholic acid.

Conditions

Cerebrotendinous Xanthomatosis

Study ID

NCT00004346

Start date

Jan, 1996

Status verified date

Dec, 2003

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

PROTOCOL ENTRY CRITERIA: Cerebrotendinous xanthomatosis

Study Design

Enrollment

5 participants

Primary purpose

Treatment

Interventions and Outcome Measures

Interventions

chenodeoxycholic acid

lovastatin

Central Contacts and Locations

Locations

Oregon Health and Science University

Recruiting

Portland, Oregon, United States, 97239-3098

Contacts

Sonja Connor

503-494-7775connors@ohsu.edu

More Information

Sponsor

National Center for Research Resources (NCRR)

Last update posted

Jun 24, 2005

Last verified

Dec, 2003

Keywords

  • cerebrotendinous xanthomatosis
  • inborn errors of metabolism
  • rare disease

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by National Center for Research Resources (NCRR) on 2005-06-24.