Recruiting
Phase 2

Dietary Cholesterol

Sponsor:

National Center for Research Resources (NCRR)

Code:

NCT00004347

Conditions

Smith-Lemli-Opitz Syndrome

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

diet

Study Details

Brief summary:

OBJECTIVES: I. Examine the intestinal absorption of dietary cholesterol in patients with Smith-Lemli-Opitz syndrome.

II. Measure the effect of dietary cholesterol on plasma sterol composition. III. Quantify basal cholesterol synthesis, turnover of cholesterol and 7-dehydrocholesterol, and the effects of dietary cholesterol on these parameters.

IV. Identify fecal bile acid excretion quantitatively and qualitatively in these patients.

V. Compare the incorporation of deuterated water into plasma cholesterol, 7-dehydrocholesterol, and other intermediates, and assess the effect of dietary cholesterol on this incorporation.

Conditions

Smith-Lemli-Opitz Syndrome

Study ID

NCT00004347

Start date

Nov, 1995

Status verified date

Dec, 2003

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

PROTOCOL ENTRY CRITERIA:

Smith-Lemli-Opitz syndrome

Study Design

Enrollment

5 participants

Primary purpose

Treatment

Interventions and Outcome Measures

Interventions

diet

Central Contacts and Locations

Locations

Oregon Health and Science University

Recruiting

Portland, Oregon, United States, 97239-3098

Contacts

Sonja Connor

503-494-7775connors@ohsu.edu

Jennifer Penfield

503-494-7944penfield@ohsu.edu

More Information

Sponsor

National Center for Research Resources (NCRR)

Last update posted

Jun 24, 2005

Last verified

Dec, 2003

Keywords

  • Smith-Lemli-Opitz syndrome
  • genetic diseases and dysmorphic syndromes
  • rare disease

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by National Center for Research Resources (NCRR) on 2005-06-24.