Recruiting

Insulin-Like Growth Factor-I

Sponsor:

National Center for Research Resources (NCRR)

Code:

NCT00005105

Conditions

Intrauterine Growth Retardation

Eligibility Criteria

Sex: All

Age: 1 - 18

Healthy Volunteers: Not accepted

Study Details

Brief summary:

OBJECTIVES:

I. Determine if mutations in the gene encoding the insulin-like growth factor-I receptor lead to relative insulin-like growth factor-I insensitivity and produce intrauterine growth retardation in children.

Conditions

Intrauterine Growth Retardation

Study ID

NCT00005105

Start date

Jan, 1997

Status verified date

Dec, 2003

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 1 - 18

Healthy Volunteers: Not accepted

  • Intrauterine growth retardation (IUGR), defined as birth weight less than 2 standard deviations below the mean by Usher and McLean Deficient "catch-up" growth (stature less than 5th percentile on growth chart after age 18 months) Normal or elevated circulating concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) IGF-I or IGFBP-3 within or above the 95th percentile confidence interval for age No other clinical explanation for poor prenatal and postnatal growth No IUGR due to maternal toxemia, endocrine disease, gastrointestinal disease, significant heart disease, or chromosomal abnormalities No other condition known to retard growth

Study Design

Enrollment

75 participants

Interventions and Outcome Measures

Central Contacts and Locations

Locations

Schneider Children's Hospital

Recruiting

New Hyde Park, New York, United States, 11042

Contacts

Graeme Frank

718-470-3390

Children's Hospital Medical Center - Cincinnati

Recruiting

Cincinnati, Ohio, United States, 45229-3039

Contacts

Steven D. Chernausek

513-636-4744

Medical College of Virginia School of Medicine

Recruiting

Richmond, Virginia, United States, 23298-0230

Contacts

Paul Kaplowitz

804-786-9788

More Information

Sponsor

National Center for Research Resources (NCRR)

Last update posted

Jun 24, 2005

Last verified

Dec, 2003

Keywords

  • endocrine disorders
  • intrauterine growth retardation
  • rare disease

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by National Center for Research Resources (NCRR) on 2005-06-24.