Recruiting

Observational Study

Sponsor:

National Institute of Neurological Disorders and Stroke (NINDS)

Code:

NCT00009243

Conditions

Brain Disease

Ischemic Attack, Transient

Cerebrovascular Accident

Cerebrovascular Disorder

Vascular Diseases

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to learn more about stroke and obtain information that may serve as the basis for future investigations. It will 1) establish a registry of patients with cerebrovascular disease (stroke); 2) characterize the natural history of acute stroke and transient ischemic attacks (TIA)-an interruption of blood flow to the brain that causes stroke symptoms for a short period of time); and 3) evaluate the data to generate ideas for future studies.

Patients 18 years of age or older with suspected acute stroke or TIA may be eligible for this study. Subjects will be recruited from patients who present with stroke at the emergency department of Suburban Hospital in Bethesda, Maryland.

The study will gather data collected from diagnostic and laboratory tests the patient undergoes as part of standard medical care, including findings of medical and neurological examinations and other tests. In addition, studies will be done for research purposes only to gather data about stroke and TIA. These may include the following:

  • Blood and urine tests not more than 2 tablespoons of blood will be drawn for various tests.
  • Electrocardiogram (EKG) (heart tracing)-electrodes placed on the chest wall detect the heartbeat and heart rhythm.
  • Computed tomography (CT) scan of the head-specialized X-rays are used to obtain images of the brain.
  • Magnetic resonance imaging (MRI) of the brain-a strong magnetic field and radio waves are used to produce images that provide information about the brain tissue and blood vessels.
  • Transcranial Doppler (TCD)-sound waves are used to image the arteries of the brain and neck.
  • Echocardiogram-sound waves are used to image the heart and evaluate heart function.

Patients may be asked to return to Suburban Hospital for follow-up testing in 1, 3, and/or 12 months, when some of these tests may be repeated to assess changes over time

Conditions

Brain Disease

Ischemic Attack, Transient

Cerebrovascular Accident

Cerebrovascular Disorder

Vascular Diseases

Study ID

NCT00009243

Start date

Jan 26, 2001

Status verified date

Oct 1, 2026

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

  • INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Aged >=18
2. Presented to participating study site (ED, ICU, or inpatient unit) with or at risk of acute stroke, TIA, or other disturbances of cerebrovascular circulation

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. Subjects with contraindication to MRI scanning will be excluded from any testing which involves the use of MRI. The contraindications include subjects with the following devices or conditions:

  • Central nervous system aneurysm clips
  • Implanted neural stimulator
  • Implanted cardiac pacemaker or defibrillator
  • Cochlear implant
  • Ocular foreign body (e.g. metal shavings)
  • Insulin pump
  • Metal shrapnel or bullet
  • Any implanted device that is incompatible with MRI

Subjects with a condition precluding entry in the scanner (e.g. morbid obesity, Claustrophobia, etc.) will not be included in the MRI portion of this study.
2. Pregnancy

Study Design

Enrollment

4000 participants

Anticipated

Interventions and Outcome Measures

Arms

Patients

Patients with acute stroke symptoms

Primary outcome measure

  • Prevalence and type of abnormalities seen on neuroimaging as a function of time from acute insult [ Time Frame: Post-acute, 24 hours, 5 days/discharge, 30 days ]

Central Contacts and Locations

Central contacts

Nicole L Peterkin

(301) 435-2395nicole.peterkin@nih.gov

Lawrence L Latour, Ph.D.

(301) 435-2395latourl@ninds.nih.gov

Locations

Medstar Washington Hospital Center

Recruiting

Washington D.C., District of Columbia, United States, 20010

Contacts

Lawrence Latour, Ph.D.

301-435-2395latourl@ninds.nih.gov

Suburban Hospital - Johns Hopkins Medicine

Recruiting

Bethesda, Maryland, United States, 20814

Contacts

Lawrence Latour, Ph.D.

301-435-2395latourl@ninds.nih.gov

National Institutes of Health Clinical Center

Recruiting

Bethesda, Maryland, United States, 20892

Contacts

For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

800-411-1222ccopr@nih.gov

More Information

Sponsor

National Institute of Neurological Disorders and Stroke (NINDS)

Last update posted

Oct 5, 2026

Last verified

Oct 1, 2026

Keywords

  • Stroke
  • Natural History
  • MRI (Magnetic Resonance Imaging)
  • Magnetic Resonance Imaging
  • Acute Stroke
  • TIA

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-08. This information was provided to ClinicalTrials.gov by National Institute of Neurological Disorders and Stroke (NINDS) on 2026-10-05. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.