Recruiting

Observational Study

Sponsor:

National Institute of Dental and Craniofacial Research (NIDCR)

Code:

NCT00024804

Conditions

Tumor Induced Osteomalcia

Osteomalacia

Familial Tumoral Calcinosis

Eligibility Criteria

Sex: All

Age: 0 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This study has four objectives: 1) to provide investigators the opportunity to study bone specimens from patients with various skeletal diseases; 2) to treat patients with skeletal diseases at the NIH; 3) to expose NIH trainees to certain skeletal diseases; and 4) to gain more knowledge about skeletal diseases and stimulate further study of bone biology.

Anyone with a disease that affects the skeleton may be eligible for this study.

All evaluations, tests, procedures and treatments given study participants are used in the standard care of skeletal diseases. No experimental evaluations or treatments are offered. Patient evaluations include a medical history, review of medical records and routine physical examination. Based on the findings, other procedures may be recommended, including blood tests, urine tests, and imaging tests, such as X-rays, bone densitometry, bone scan, computed tomography (CT) and magnetic resonance imaging (MRI).

Bone specimens from participants will be collected for research use. Specimens will be obtained from bone removed during a patient s planned surgical procedure performed for medical care, or patients may be requested to have a bone biopsy removal of a small piece of bone tissue as part of the patient evaluation procedure.

...

Conditions

Tumor Induced Osteomalcia

Osteomalacia

Familial Tumoral Calcinosis

Study ID

NCT00024804

Start date

Nov 19, 2001

Status verified date

May 21, 2026

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 70+

Healthy Volunteers: Not accepted

  • INCLUSION CRITERIA:

The study population will include participants with known or suspected bone disease and/or with a known or suspected disorder of mineral metabolism. To be eligible to participate in this study, an individual must meet all of the following criteria:

1. Age 1 day of life or older
2. Have a known or suspected bone disease, as demonstrated by any one of the following: a fracture, or abnormal bone findings on x-ray, CT scan, MRI, or bone densitometry, and/or a medical or family history consistent with or suggestive of a bone disease.
3. Have a known or suspected disorder of mineral metabolism, as demonstrated by any one of the following: laboratory measurement above or below the reference values for either blood or urine calcium, phosphorus, magnesium, parathyroid hormone or vitamin D, or other measures of mineral metabolism, and/or a medical or family history consistent with or suggestive of a disorder of mineral metabolism.

EXCLUSION CRITERIA:

1\. Participants unwilling or unable to abide by the procedures of the protocol.

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

1

Subjects with known or suspected bone disease and disorder of mineral metabolism.

Primary outcome measure

  • Collection of clinical and research specimens [ Time Frame: 10 years ]

Central Contacts and Locations

Central contacts

Elizabeth A Ferguson

(240) 687-3029elizabeth.ferguson@nih.gov

Kelly B Roszko, M.D.

(301) 496-4563kelly.roszko@nih.gov

Locations

National Institutes of Health Clinical Center

Recruiting

Bethesda, Maryland, United States, 20892

Contacts

For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

800-411-1222ccopr@nih.gov

More Information

Sponsor

National Institute of Dental and Craniofacial Research (NIDCR)

Last update posted

Sep 1, 2026

Last verified

May 21, 2026

Keywords

  • Natural History
  • skeletal diseases
  • Osteoporosis
  • Dysplasia
  • Osteomalacia
  • Bone Diseases
  • Skeletal Disease

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by National Institute of Dental and Craniofacial Research (NIDCR) on 2026-09-01.