Recruiting

Observational Study

Sponsor:

Harvard University Faculty of Medicine

Code:

NCT00041600

Conditions

Brain Malformation

Neuronal Migration Disorder

Cognition Disorder

Epilepsy

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to identify genes responsible for epilepsy, brain malformations and disorders of human cognition.

Conditions

Brain Malformation

Neuronal Migration Disorder

Cognition Disorder

Epilepsy

Study ID

NCT00041600

Start date

Apr, 1996

Status verified date

Sep, 2023

Completion date

Jun, 2030

Anticipated

Primary completion date

Jun, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

INCLUSION:

  • Males and females of any age.
  • Persons with a brain malformation or disorder of cognition (familial intellectual disability \[previously known as mental retardation\] or autism).

EXCLUSION:

  • Persons without a brain malformation or disorder of cognition (familial intellectual disability (previously known as mental retardation\] or autism).

Study Design

Enrollment

3500 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Identification and characterization of genes important in normal brain development and associated with brain malformations. [ Time Frame: Ongoing ]

Central Contacts and Locations

Central contacts

Jennifer Neil, MS

617-919-2865walshresearch@childrens.harvard.edu

Abbe Lai, MS

617-919-4371

Locations

Boston Children's Hospital, Walsh Laboratory

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Jennifer Neil, MS

617-919-2865walshresearch@childrens.harvard.edu

Abbe Lai, MS

617-919-4371

Principal Investigator:

Christopher A. Walsh, M.D., Ph.D.

More Information

Sponsor

Harvard University Faculty of Medicine

Last update posted

Sep 21, 2023

Last verified

Sep, 2023

Keywords

  • epilepsy
  • seizures
  • disorders of human cognition
  • neuronal migration
  • neuronal migration disorders
  • lissencephaly
  • schizencephaly
  • polymicrogyria
  • heterotopia
  • microcephaly
  • pachygyria

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Harvard University Faculty of Medicine on 2023-09-21.