Recruiting

Observational Study

Sponsor:

Dana-Farber Cancer Institute

Code:

NCT00131014

Conditions

Non-Hodgkin's Lymphoma

Hodgkin's Disease

Leukemia, Lymphocytic, Chronic

Lymphoproliferative Disorders

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to investigate possible genetic factors that contribute to the development of lymphomas. The databank will be used to determine whether familial lymphomas have unique genetic characteristics different from sporadic lymphomas and to attempt to identify a gene that confers an increased risk of lymphoma.

Conditions

Non-Hodgkin's Lymphoma

Hodgkin's Disease

Leukemia, Lymphocytic, Chronic

Lymphoproliferative Disorders

Study ID

NCT00131014

Start date

Aug 9, 2004

Status verified date

Apr, 2026

Completion date

Jan, 2033

Anticipated

Primary completion date

Jan, 2033

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Any individual diagnosed with non-Hodgkin's lymphoma or Hodgkin's disease or chronic lymphocytic leukemia (CLL), who has a 1st degree relative (parent, sibling or child) with a lymphoproliferative disorder; or families in which the individual has a lymphoproliferative disorder, and an unusual clustering of frequent or premature solid tumors is also observed.
  • Family members of the individual, either affected or unaffected with lymphoma, who are contacted by the individual and agree to participate in the study.
  • Deceased family members may be included in the study. Public records such as death certificates may be used to confirm the history. Consent for medical records or tissue blocks will be obtained from the deceased family member's next of kin. The hierarchy of relatives defined as next of kin is spouse, offspring, parents and siblings. Archived tissue samples may be used for genetic research.
  • Age > 18 years

Exclusion Criteria:

  • Subjects without a family history of lymphoma

Study Design

Enrollment

1500 participants

Anticipated

Interventions and Outcome Measures

Arms

Next of Kin of deceased subj by lymphoma

Next of Kin of deceased subject by lymphoma

Subject unaffected by lymphoma

Subject unaffected by lymphoma

Subject affected by lymphoma

Subject affected by lymphoma

Primary outcome measure

  • Genetic factors that contribute to the development of lymphomas and CLL [ Time Frame: Indefinite ]

Central Contacts and Locations

Central contacts

Celeste Carey, MS

857-215-1646celeste_carey@dfci.harvard.edu

Jennifer Brown, MD PhD

617-632-4564Jennifer_Brown@dfci.harvard.edu

Locations

Dana-Farber Cancer Institute

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Jennifer R. Brown, MD, PhD

617-632-6692jennifer_brown@dfci.harvard.edu

Principal Investigator:

Jennifer R. Brown, MD, PhD

More Information

Sponsor

Dana-Farber Cancer Institute

Last update posted

Apr 24, 2026

Last verified

Apr, 2026

Keywords

  • Non-Hodgkin's Lymphoma
  • Hodgkin's disease
  • Chronic Lymphocytic Leukemia
  • Lymphoproliferative disorder
  • Genetics

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Dana-Farber Cancer Institute on 2026-04-24.