Recruiting

Observational Study

Sponsor:

University of Miami

Code:

NCT00136500

Conditions

Amyotrophic Lateral Sclerosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

CRiALS is an umbrella protocol through which people are recruited to participate in a range of research studies being conducted by the ALS Research Collaboration (ARC).

Conditions

Amyotrophic Lateral Sclerosis

Study ID

NCT00136500

Start date

Feb, 2005

Status verified date

Mar, 2026

Completion date

Dec, 2037

Anticipated

Primary completion date

Dec, 2037

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

1. At least 18 years of age.
2. Member of at least one of the following categories:

1. Individuals affected with ALS or a related neurodegenerative disease (sporadic or familial)
2. Unaffected individuals from fALS pedigrees, including pre-symptomatic individuals at genetic risk for ALS or individuals from pedigrees of ALS related diseases.
3. Healthy controls
3. Able and willing to comply with relevant procedures.

Exclusion Criteria:

1\. Subject has a condition or is in a situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol -- including but not limited to neurological, psychological and/or medical conditions (e.g., multiple sclerosis, neuropathy, myelopathy).

Study Design

Enrollment

10000 participants

Anticipated

Interventions and Outcome Measures

Arms

Individuals affected with ALS

This population be sporadic or familial ALS.

Unaffected individuals from families in which the genetic cause of ALS is known

This population includes pre-symptomatic individuals at genetic risk for ALS or a related neurodegenerative disorder (i.e., FTD).

Individuals affected with an ALS-related neurodegenerative disease

This would include FTD, MSP, IBMPFD, etc.

Healthy controls

Primary outcome measure

  • Recruitment [ Time Frame: Annually ]

Central Contacts and Locations

Central contacts

Anne-Laure Grignon, MD

888-413-9315fals@med.miami.edu

Locations

University of Miami

Recruiting

Miami, Florida, United States, 33136

Contacts

Anne-Laure Grignon, MD

888-413-9315fals@med.miami.edu

More Information

Sponsor

University of Miami

Last update posted

Mar 20, 2026

Last verified

Mar, 2026

Keywords

  • genetics
  • biomarkers
  • pre-symptomatic
  • natural history

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Miami on 2026-03-20.