Recruiting

Observational Study

Sponsor:

Johns Hopkins University

Code:

NCT00181233

Conditions

Sudden Cardiac Death

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Sudden cardiac death is a tragic event that strikes all age groups and is unfortunately increasing in prevalence. Because it is difficult to predict those at highest risk, this study is designed to test the hypothesis that new imaging techniques (magnetic resonance imaging \[MRI\] and computed tomography \[CT\]) are useful for identifying factors which put people at high risk for sudden death.

Conditions

Sudden Cardiac Death

Study ID

NCT00181233

Start date

Oct, 2003

Status verified date

Jan, 2026

Completion date

Jul, 2029

Anticipated

Primary completion date

Feb, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Left ventricular ejection fraction <or = 35%
  • Planned implantable cardioverter-defibrillator (ICD) implantation for clinical indications (primary prevention)

Exclusion Criteria:

  • History of sudden death (secondary prevention)
  • Contraindication to undergoing MRI (metallic implant, pacemaker, etc.)

Study Design

Enrollment

400 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • sudden cardiac death [ Time Frame: 6 month intervals ]
  • cardiovascular death [ Time Frame: 6 month intervals ]
  • appropriate ICD discharge [ Time Frame: 6 month intervals ]
  • composite sudden cardiac death and appropriate ICD discharge [ Time Frame: 6 month intervals ]

Central Contacts and Locations

Central contacts

Barbara Butcher, RN

443-287-3472bbutche1@jhmi.edu

Locations

Johns Hopkins Medical Institutions

Recruiting

Baltimore, Maryland, United States, 21287

Contacts

Tricia Steinberg, RN

443-287-3469asteinb3@jhmi.edu

More Information

Sponsor

Johns Hopkins University

Last update posted

Jan 14, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-01-14.