Recruiting

Observational Study

Sponsor:

Johns Hopkins University

Code:

NCT00181259

Conditions

Heart Failure, Congestive

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

Conditions

Heart Failure, Congestive

Study ID

NCT00181259

Start date

Jan, 1988

Status verified date

Mar, 2026

Completion date

Aug, 2028

Anticipated

Primary completion date

Aug, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • age > 18 years
  • Healthy subjects: no history of heart disease
  • Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) <40%
  • Left ventricular hypertrophy: wall thickness >1.2cm
  • Coronary artery disease: >50% coronary lesion or positive stress test

Exclusion Criteria:

  • contraindication to MRI

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Phosphocreatine/adenosine triphosphate (PCr/ATP) and creatine kinase (CK) flux [ Time Frame: At time of magnetic resonance spectroscopy (MRS) ]

Central Contacts and Locations

Central contacts

Robert G. Weiss, MD

410-955-1703rweiss@jhmi.edu

Locations

Johns Hopkins Medical Institutions

Recruiting

Baltimore, Maryland, United States, 21205

Contacts

Tricia Steinberg, RN, MSN

443-287-3469asteinb3@jhmi.edu

More Information

Sponsor

Johns Hopkins University

Last update posted

Mar 9, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-03-09.