Recruiting

Magnetic Stimulation

Sponsor:

St. Joseph's Healthcare Hamilton

Code:

NCT00186771

Conditions

Schizophrenia

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

Paired Pulse

Paired Pulse

Study Details

Brief summary:

Schizophrenia is a chronic, severe, and disabling brain disease. Auditory hallucinations are the most frequent symptoms with an incident of 50% to 70% in patients.

Transcranial Magnetic Stimulation (TMS) can significantly reduce symptoms of schizophrenia. TMS is capable of inducing changes in the electrical activities of the brain in humans.

The purpose of this trial is to study the use of TMS to decrease auditory hallucinations in schizophrenia.

Conditions

Schizophrenia

Study ID

NCT00186771

Start date

Nov, 2004

Status verified date

Jul, 2011

Completion date

Jan, 2015

Anticipated

Primary completion date

Jan, 2012

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Schizophrenia
  • Auditory hallucinations occuring more than 5 times per day
  • Adequate (6 weeks) trial of antipsychotic medication
  • Including at least 1 atypical antipsychotic medication
  • Medication stable for 4 weeks prior to commencement of the study
  • Competent to consent

Exclusion Criteria:

  • history of seizure disorder in patient or first degree relative
  • recent head injury
  • Acute suicidality
  • Alcohol or substance abuse
  • Implanted pacemaker or metal in head or neck
  • Pregnancy

Study Design

Enrollment

10 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: True Transcranial Magnetic Stimulation

True treatment with TMS over the temporoparietal cortex.

sham comparator: Sham Transcranial Magnetic Stimulation

Sham treatment with rTMS over the temporoparietal cortex.

Interventions

Paired Pulse

True treatment with rTMS over the temporoparietal cortex.

Paired Pulse

Sham treatment with rTMS over the temporoparietal cortex.

Primary outcome measure

  • Hoffman Auditory Hallucination Scale [ Time Frame: weekly ]

Central Contacts and Locations

Central contacts

Rose Marie Mueller, RN

905-522-1155rmueller@stjoes.ca

Sandra Chalmers, RN

905-522-1155schalmer@stjoes.ca

Locations

St. Joseph's Healthcare, rTMS Laboratory, 100 West Fifth Street

Recruiting

Hamilton, Ontario, Canada, L8N 3K7

Principal Investigator:

Gary Hasey, MD

St. Joseph's Healthcare, rTMS Laboratory, 100 West Fifth Street

Recruiting

Hamilton, Ontario, Canada, L8N 3K7

More Information

Sponsor

St. Joseph's Healthcare Hamilton

Last update posted

Jul 28, 2011

Last verified

Jul, 2011

Keywords

  • Transcranial Magnetic Stimulation
  • Paired Pulse

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by St. Joseph's Healthcare Hamilton on 2011-07-28.