Recruiting

Observational Study

Sponsor:

University Health Network, Toronto

Code:

NCT00242151

Conditions

Heart Disease

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The objective of this study is to determine prevalence of postoperative delirium and confusion in patients undergoing cardiac surgery. This proposal is a pilot study designed to evaluate effect of cardiac surgery on prevalence of delirium and confusion.

The primary aim is to evaluate prevalence of delirium and confusion in patients undergoing cardiac surgery and to determine risk factors for this condition.

A secondary aim is to evaluate organic brain injury by early postoperative diffusion weighted magnetic resonance imaging (DW-MRI) in patients who develop delirium and confusion.

The hypothesis to be tested is that patients with postoperative delirium and confusion have high incidence of organic brain injury as detected by DW-MRI.

Conditions

Heart Disease

Study ID

NCT00242151

Status verified date

Sep, 2006

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion criteria:

  • All patients undergoing cardiac surgery in our institute in 2 year period
  • Signed informed consent

Exclusion criteria:

  • Past history of transient ischemic attacks, stroke, symptomatic carotid artery disease.
  • Past history of psychiatric disorders
  • History of alcohol and drug abuse
  • History of severe kidney or liver disease (creatinine >2.5mg/dL and bilirubin > 2mg/dL)
  • Known contraindications to MRI

Study Design

Enrollment

100 participants

Interventions and Outcome Measures

Central Contacts and Locations

Central contacts

Jo A Carroll, RN

416-340-4800jo.carroll@uhn.on.ca

Locations

Toronto General Hospital, University Health Network

Recruiting

Toronto, Ontario, Canada, M5G 2C4

Contacts

Jo A Carroll, RN

416-340-4800jo.carroll@uhn.on.ca

More Information

Sponsor

University Health Network, Toronto

Last update posted

Oct 12, 2006

Last verified

Sep, 2006

Keywords

  • Delirium, Confusion, Cardiac Surgery, Organic Brain Injury, Diffusion Weighted Magnetic Resonance Imaging (DW-MRI)

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University Health Network, Toronto on 2006-10-12.