Recruiting

Predicting Responsiveness

Sponsor:

Hamilton Health Sciences Corporation

Code:

NCT00243555

Conditions

Peanut Hypersensitivity

Eligibility Criteria

Sex: All

Age: 5+

Healthy Volunteers: Accepted

Interventions

allergy skin testing

venepuncture

Study Details

Brief summary:

The purpose of this study is to develop a tool to better predict clinical allergy to peanut, so that those who are skin test positive but non allergic will not have to unnecessarily avoid peanut, and those with true allergy can be diagnosed, possibly without oral ingestion challenge, and treated appropriately

Conditions

Peanut Hypersensitivity

Study ID

NCT00243555

Start date

Sep, 2002

Status verified date

Sep, 2006

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 5+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 5 years of age and older
  • Informed consent (Subject has provided an appropriately signed and dated informed consent. An appropriately signed and dated assent must be obtained from the parents or guardian if the subject is a child under 18 years of age.)
  • Free of any clinically significant disease, such as uncontrolled asthma, which may interfere with study evaluations

Group 1:

  • skin test positive to peanut
  • documented clinical history of peanut allergy. A documented clinical history may include symptoms such as hives,swelling of the mouth or tongue, throat closing sensation, shortness of breath, wheezing, lightheadedness, anaphylaxis.

Group 2:

  • Positive skin test to peanut
  • History of being able to tolerate peanut exposure without problems

Group 3:

  • Positive skin test to peanut
  • No known ingestion of peanut

Group 4:

  • Negative skin test to peanut
  • Negative skin test to other food and environmental allergens
  • Able to tolerate peanut exposure without problems

Exclusion Criteria:

  • Women who are pregnant or nursing
  • use of antihistamines or decongestant therapy four days prior to clinic visit
  • use of nasal or inhaled corticosteroid in the 1 month period prior to clinic visit
  • use of non-steroidal anti-inflammatory drugs (NSAIDS) in the week prior to clinic visit
  • Moderate or severe/ uncontrolled asthma (defined as the use of more than 4 puffs of ventolin per day, not including prophylactic medications prior to exercise)
  • Symptomatic allergic rhinitis
  • Patients who had an acute allergic reaction to food, drugs, and bee sting in the 1 month period prior to clinic visit
  • Use of an epi-pen during the past month
  • respiratory infection one month prior to clinic visit
  • immunotherapy

Study Design

Enrollment

60 participants

Interventions and Outcome Measures

Interventions

allergy skin testing

venepuncture

Central Contacts and Locations

Central contacts

Andrea Marin, MD

905-521-2100

Locations

Hamilton Health Sciences Corporation, McMaster Site

Recruiting

Hamilton, Ontario, Canada, L8N 3Z5

Contacts

Marie Townsend

905-525-9140hsresadm@mcmaster.ca

Deidre L. Henne

905-521-2100henne@hhsc.ca

More Information

Sponsor

Hamilton Health Sciences Corporation

Last update posted

Feb 1, 2007

Last verified

Sep, 2006

Keywords

  • peanut hypersensitivity
  • chemokines
  • cytokines
  • RNA,messenger
  • monocytes

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Hamilton Health Sciences Corporation on 2007-02-01.