Recruiting

Lung Cancer

Sponsor:

NYU Langone Health

Code:

NCT00301119

Conditions

Lung Cancer

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

Study Details

Brief summary:

RATIONALE: Screening tests that use biomarkers may help doctors find tumor cells early and plan effective treatment for lung cancer.

PURPOSE: This clinical trial is studying biomarkers in screening participants for lung cancer.

Conditions

Lung Cancer

Study ID

NCT00301119

Start date

May, 2000

Status verified date

May, 2026

Completion date

May, 2030

Anticipated

Primary completion date

May, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

DISEASE CHARACTERISTICS:

  • Screening Cohort

  • At high- or low-risk for lung cancer
  • Smoking history ≥ 20 pack years\*

  • With or without workplace exposure to asbestos
  • NOTE: \* Participants with < 20 pack years of smoking are eligible if 50 years of age or older
  • Rule-Out Lung cancer group

  • Referred for evaluation of suspicious nodules with 1 of the following diagnoses:

  • Lung cancer
  • Nonmalignant nodules (control group)

PATIENT CHARACTERISTICS:

  • Not pregnant
  • No prior malignancy except nonmelanoma skin cancer

PRIOR CONCURRENT THERAPY:

  • Not specified

Study Design

Enrollment

3606 participants

Anticipated

Interventions and Outcome Measures

Arms

lung cancer screening cohort

observational only. no intervention. current, former and never smokers over age 50 without history of cancer, except for non melanoma skin cancer, no previous treatment with chemotherapy.

r/o lung cancer

observational only. no intervention. patients with CT findings suspicious for lung cancer who are undergoing bronchoscopy and/or surgery.

Primary outcome measure

  • Lung cancer diagnosis as measured by CT scan findings and pathology findings annually [ Time Frame: 07/01/2015 ]

Central Contacts and Locations

Central contacts

James J. Tsay, MD, MSc

212-598-6351Jun-Chieh.Tsay@nyulangone.org

Rosemary M Schluger

212-263-0255rosemary.schluger@nyulangone.org

Locations

NYU Cancer Institute at New York University Medical Center

Recruiting

New York, New York, United States, 10016

Contacts

James J. Tsay, MD, MSc

212-598-6351Jun-Chieh.Tsay@nyulangone.org

More Information

Sponsor

NYU Langone Health

Last update posted

May 8, 2026

Last verified

May, 2026

Keywords

  • small cell lung cancer
  • non-small cell lung cancer
  • smoker lung cancer screening
  • low dose spiral CT screening

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by NYU Langone Health on 2026-05-08.