Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT00305305

Conditions

Brain Disorders

Aicardi Syndrome

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Dr. Elliott Sherr and his collaborators at University of California, San Francisco (UCSF) are studying the genetic causes of disorders of cognition and epilepsy, in particular disorders of brain development that affect the corpus callosum, such as Aicardi syndrome, as well as two additional brain malformations, polymicrogyria and Dandy-Walker malformation. The goal of the investigators' research is to use a better understanding of the underlying genetic causes as a foundation to develop better treatments for these groups of patients.

Conditions

Brain Disorders

Aicardi Syndrome

Study ID

NCT00305305

Start date

Aug, 2003

Status verified date

Aug, 2026

Completion date

Jan, 2027

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Clinical diagnosis of agenesis or dysgenesis of the corpus callosum, polymicrogyria, or Dandy-Walker malformation
  • Should be confirmed by an MRI (Magnetic Resonance Imaging) of the brain

Exclusion Criteria:

  • Fully formed but hypoplastic corpus callosum

Study Design

Enrollment

2000 participants

Anticipated

Interventions and Outcome Measures

Central Contacts and Locations

Central contacts

Carolyn Le, BA, BS

415-502-8039Carolyn.Le@ucsf.edu

Locations

University of California, San francisco

Recruiting

San Francisco, California, United States, 94143

More Information

Sponsor

University of California, San Francisco

Last update posted

Aug 17, 2026

Last verified

Aug, 2026

Keywords

  • Agenesis Corpus Callosum
  • Polymicrogyria
  • Dandy-Walker
  • Brain Malformation
  • Autism
  • Epilepsy
  • Mental Retardation
  • MRI
  • Agenesis of the Corpus Callosum (complete or partial)
  • Confirmed by a brain MRI.
  • Aicardi Syndrome.

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-08-17.