Recruiting

Observational StudyCooperative Huntington's Observational Research Trial

Sponsor:

HP Therapeutics Foundation

Code:

NCT00313495

Conditions

Huntington Disease

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The purpose of this study is to collect prospective data from individuals who are part of a Huntington Disease (HD) family, in order to relate phenotypes between individuals and families with each other and genetic factors in order to learn more about HD, develop potential treatments for HD, and to plan for future research studies of experimental drugs aimed at slowing or postponing the onset and progression of HD.

Conditions

Huntington Disease

Study ID

NCT00313495

Start date

Feb, 2006

Status verified date

Mar, 2011

Completion date

Dec, 2020

Anticipated

Primary completion date

Dec, 2020

Anticipated

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Inclusion Criteria:

(1) MANIFEST/PRE-MANIFEST HD: Individuals of any age who are affected by HD OR an individual 18 years or older who - has tested positive for the HD gene.
(2) INDIVIDUALS AT RISK: An individual 18 years or older who has not undergone DNA testing for the mutation responsible for HD and who is a first degree relative (parent, sibling, child) of an individual with Manifest or pre-manifest HD OR an older adolescent 15 to 17 years of age who has a parent with manifest HD or pre-manifest HD enrolled in COHORT.
(3) ADULTS AT SECONDARY RISK: An individual 18 years of age or older who has not undergone DNA testing for the mutation responsible for HD and is a grandparent or grandchild of an individual enrolled in COHORT who has manifest HD or pre-manifest HD
(4) CONTROL: A spouse or caregiver, 18 years of age or older, of an individual enrolled in COHORT who has manifest HD or pre-manifest HD
(5) ADULT GENE NEGATIVE: An individual, 18 years of age or older, with a family history of HD who has undergone DNA testing and does not carry the genetic mutation responsible for HD.

Exclusion Criteria:

(1) Anyone who does not fit the inclusion criteria

Study Design

Enrollment

5000 participants

Anticipated

Interventions and Outcome Measures

Central Contacts and Locations

Central contacts

Huntington Study Group

800-487-7671

Locations

UCLA School of Medicine

Recruiting

Los Angeles, California, United States

Contacts

Angeline Gratiano

310-206-2154 agratiano@mednet.ucla.edu

University of California, Davis

Recruiting

Sacramento, California, United States

Contacts

Nicole Mans

916-734-3541 nicole.mans@ucdmc.ucdavis.edu

University of California, San Diego

Recruiting

San Diego, California, United States

Contacts

jody goldstein

858-622-5854 jlgoldstein@ucsd.edu

University of California, San Francisco

Recruiting

San Francisco, California, United States, 94143

Contacts

Jonathan Gooblar, BA

415-476-1686 jgooblar@memory.ucsf.edu

Colorado Neurological Institute

Recruiting

Littleton, Colorado, United States

Contacts

Diane Erickson

303-762-6674 derickson@thecni.org

University of Connecticut

Recruiting

Hartford, Connecticut, United States

Contacts

Mary Jane Fitzpatrick

860-679-4441 fitzpatrick@psychiatry.uchc.edu

Institutue for Neurodegenerative Disorders

Recruiting

New Haven, Connecticut, United States

Contacts

Candace Cotto

203-401-4339 ccotto@indd.org

University of Miami School of Medicine

Recruiting

Miami, Florida, United States

Contacts

Monica Quesada

305-243-3647 mquesada2@med.miami.edu

University of South Florida

Recruiting

Tampa, Florida, United States

Contacts

Marcia McCall

813-974-6022 mamccall@hsc.usf.edu

Emory University

Recruiting

Atlanta, Georgia, United States

Contacts

Elaine Sperin

404-728-4786 esperin@emory.edu

Medical College of Georgia

Recruiting

Augusta, Georgia, United States

Contacts

Buff Farrow

706-721-0619 bfarrow@georgiahealth.edu

Rush University Medical Center

Recruiting

Chicago, Illinois, United States

Contacts

Jeana Jaglin

312-942-5003 jjaglin2@rush.edu

University of Chicago

Recruiting

Chicago, Illinois, United States

Contacts

Joan Young

773-702-4392 jyoung@neurology.bsd.uchicago.edu

Indiana University School of Medicine

Recruiting

Indianapolis, Indiana, United States

Contacts

Melissa Wesson

317-274-2390 mkwesson@iupi.edu

University of Iowa

Recruiting

Iowa City, Iowa, United States

Contacts

Michelle Harreld

319-384-1174 michelle-harreld@uiowa.edu

University of Kansas Medical Center

Recruiting

Kansas City, Kansas, United States

Contacts

Hillary Dubinsky

913-945-5019 hdubinsky@kumc.edu

Hereditary Neurological Disease Center

Recruiting

Wichita, Kansas, United States

Contacts

Greg Suter

316-721-9250 hndcentre@aol.com

University of Louisville

Recruiting

Louisville, Kentucky, United States, 40294

Contacts

Annette Robinson

502-540-3585 annette.robinson@louisville.edu

Johns Hopkins University

Recruiting

Baltimore, Maryland, United States

Contacts

Claire Welsh

410-955-1349 cswelsh@jhmi.edu

University of Maryland

Recruiting

Baltimore, Maryland, United States

Contacts

Lauren Doyle

410-328-3339 ldoyle@upi.umaryland.edu

Boston University School of Medicine

Recruiting

Boston, Massachusetts, United States

Contacts

Melissa Diggin

617-638-7704 melissa.diggin@bmc.org

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States

Contacts

Robert McInnis

617-723-5694 rmcinnis@partners.org

Washington University School of Medicine

Recruiting

St. Louis, Missouri, United States

Contacts

Stacey Barton

314-362-3471 bartons@neuro.wustl.edu

Albany Medical College

Recruiting

Albany, New York, United States

Contacts

Sharon Evans

518-262-6611 evanss@mail.amc.edu

Columbia University

Recruiting

New York, New York, United States

Contacts

Ronda Clouse

212-305-2387 clouser@sergievsky.cpmc.columbia.edu

University of Rochester

Recruiting

Rochester, New York, United States

Contacts

Amy Chesire

585-341-7519 amy.chesire@ctcc.rochester.edu

Duke University Medical Center

Recruiting

Durham, North Carolina, United States

Contacts

Sarah Wyne

919-668-2837 wyne1991@duke.edu

Wake Forest University Baptist Medical Center

Recruiting

Winston Salem, North Carolina, United States

Contacts

Christine O'Neill

336-716-8611 coneil@iupui.edu

University of Cincinnati

Recruiting

Cincinnati, Ohio, United States

Contacts

Mary Beth Bialick

513-558-0018 howardb33@aol.com

The Cleveland Clinic

Recruiting

Cleveland, Ohio, United States

Contacts

Christine Reece

216-445-9833 houser@ccf.org

Ohio State University

Recruiting

Columbus, Ohio, United States

Contacts

Allison Seward

614-688-8672 allison.seward@osumc.edu

University of Pennsylvania

Recruiting

Philadelphia, Pennsylvania, United States

Contacts

Iman Affan

215-829-3582 iman.affan@uphs.upenn.edu

University of Pittsburgh

Recruiting

Pittsburgh, Pennsylvania, United States

Contacts

Nancy Lucarelli

412-692-4659 lucarellina2@upmc.edu

University of Tennessee-Memphis

Recruiting

Memphis, Tennessee, United States

Contacts

Nathan Jones

901-448-6180 njones37@utmem.edu

Southwestern Medical Center

Recruiting

Dallas, Texas, United States, 75390

Contacts

Giselle Huet, MS

214-648-0378 giselle.huet@utsouthwestern.edu

Amit Gode, MPH

214-648-0417 amit.gode@utsouthwestern.edu

Baylor College of Medicine

Recruiting

Houston, Texas, United States

Contacts

Tiffany Reedus

713-798-7438 treedus@bcm.edu

University of Utah

Recruiting

Salt Lake City, Utah, United States, 84108

Contacts

Paola Wall

801-581-4543 paola.wall@hsc.utah.edu

University of Virginia

Recruiting

Charlottesville, Virginia, United States

Contacts

Robert Davis

434-243-5692 rbd4n@virginia.edu

Booth Gardner Parkinsons Center

Recruiting

Kirkland, Washington, United States, 98034

Contacts

Marsha Merrick

425-899-3115 mgmerrick@evergreenhealthcare.org

University of Calgary Medical Clinic

Recruiting

Calgary, Alberta, Canada

Contacts

Mary Lou Klimek

403-210-8548 klimek@ucalgary.ca

University of British Columbia

Recruiting

Vancouver, British Columbia, Canada

Contacts

Allison Coleman

604-822-7739 allison@cmmt.ubc.ca

Movement Disorder Clinic Deer Lodge Centre

Recruiting

Winnipeg, Manitoba, Canada

Contacts

Sandra Funk

204-940-8547 sfunk@mdc-dlc.ca

Movement Disorders Clinic, Deer Lodge Centre

Recruiting

Winnipeg, Manitoba, Canada

Contacts

Sandra Funk

204-940-8547 sfunk@mdc-dlc.ca

Halifax Infirmary

Recruiting

Halifax, Nova Scotia, Canada, B3H1V7

Contacts

Joanne Courtney-Walker

902-473-8261 joanne.walker@cdha.nshealth.ca

London Health Sciences Centre

Recruiting

London, Ontario, Canada, N6A 5A5

Contacts

Emilija Makaji, MSC

519-685-8500 emilija.makaji@lhsc.on.ca

The Centre for Addiction and Mental Health

Recruiting

Markham, Ontario, Canada

Contacts

Irita Karmalkar

905-472-7082 ikarmalkar@movementdisorders.ca

Hotel-Dieu Hospital-CHUM

Recruiting

Montreal, Quebec, Canada

Contacts

Suzanne Paris

514-890-8000 suzanne.paris.chum@ssss.gouv.qc.ca

More Information

Sponsor

HP Therapeutics Foundation

Last update posted

Mar 7, 2011

Last verified

Mar, 2011

Keywords

Huntington disease, observational, family members, biomarker

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by HP Therapeutics Foundation on 2011-03-07.