Recruiting

Observational Study

Sponsor:

Massachusetts General Hospital

Code:

NCT00319722

Conditions

Autism

Eligibility Criteria

Sex: All

Age: 0 - 8

Healthy Volunteers: Accepted

Study Details

Brief summary:

This study uses EEG to study brain waves at rest and in response to specific auditory and visual sensory stimuli in autistic children. We hypothesize that, compared to same age peers, autistics will show abnormalities in their electrophysiologic processing of sounds (tones and phonemes)and visual stimuli (flashes of light)and that these abnormalities will be able to separate autistics not only from typical children but also into clinical subgroups with specific biological/electrophysiological characteristics. We hope to find biological measures which will prove diagnostic of autism in very young children and which can be used in the measurement of treatment outcome in future intervention trials.

Conditions

Autism

Study ID

NCT00319722

Start date

Feb, 2006

Status verified date

May, 2010

Completion date

Mar, 2011

Anticipated

Primary completion date

Mar, 2011

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 8

Healthy Volunteers: Accepted

Inclusion Criteria:

autistic children or their younger siblings between the ages of 3 months to 8 year

Controls: typically developing children 3mo to 8 years without known language or social disorder and not related to child with autism

Exclusion Criteria: progressive encephalopathy, treatment with multiple antiepileptic drugs, known genetic diagnosis.

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Study Design

Enrollment

130 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • EEG and ERP abnormalities [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

Locations

MGH LADDERS Clinic

Recruiting

Lexington, Massachusetts, United States, 02421

Contacts

Katherine M. Martien, M.D.

781-860-1720kmartien@partners.org

Principal Investigator:

Katherine M. Martien, M.D.

More Information

Sponsor

Massachusetts General Hospital

Last update posted

May 4, 2010

Last verified

May, 2010

Keywords

  • autism
  • pervasive developmental disorder
  • evoked potentials
  • EEG
  • Coherence

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2010-05-04.