Recruiting

Guanfacine

Sponsor:

Icahn School of Medicine at Mount Sinai

Code:

NCT00358969

Conditions

Borderline Personality Disorder

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

guanfacine (Tenex)

Study Details

Brief summary:

This study is designed to investigate whether guanfacine (Tenex) is an effective treatment for borderline personality disorder (BPD), an illness often characterized by unstable mood and impulsive aggression. Guanfacine stimulates activity in the front portion of the brain, a region associated with attention and the control of behavior. We believe that guanfacine may improve symptoms of BPD by improving attention and aiding regulation of behavior.

Conditions

Borderline Personality Disorder

Study ID

NCT00358969

Start date

Jul, 2006

Status verified date

Jul, 2006

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Inclusion Criteria: This study includes men and women between the ages of 18 and 55 who meet criteria for borderline personality disorder with impulsive aggression.

Exclusion Criteria: Subjects must not currently be taking any psychiatric medications. Subjects must not meet criteria for current substance dependence, current major depression, bipolar disorder, or schizophrenia-spectrum disorders.

Study Design

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Interventions

guanfacine (Tenex)

Primary outcome measure

  • measures of impulsive aggression [ Time Frame: undefined ]
  • measures of affective disturbance [ Time Frame: undefined ]
  • measures of social and occupational functioning [ Time Frame: undefined ]
  • measures of overall clinical status [ Time Frame: undefined ]

Central Contacts and Locations

Central contacts

Emily Hart

(212) 241-4459mpgroup@mssm.edu

David Meyerson

(212) 241-9734david.meyerson@mssm.edu

Locations

Mount Sinai Hospital - Mood & Personality Research Group

Recruiting

New York, New York, United States, 10029

More Information

Sponsor

Icahn School of Medicine at Mount Sinai

Last update posted

Aug 1, 2006

Last verified

Jul, 2006

Keywords

  • borderline personality disorder
  • guanfacine
  • impulsivity
  • aggression
  • affective instability

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Icahn School of Medicine at Mount Sinai on 2006-08-01.