Recruiting
Phase 1
Phase 2

AQ4N

Sponsor:

Novacea

Code:

NCT00394628

Conditions

Glioblastoma Multiforme

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

AQ4N

Temozolomide

Radiotherapy

Study Details

Brief summary:

Phase 1b of the study, will evaluate the safety and tolerability of AQ4N treatment at three different dose levels.

Phase 2a of the study, will further evaluate the safety, tolerability, and in addition efficacy of AQ4N treatment at a tolerated dose selected from Phase 1b.

Conditions

Glioblastoma Multiforme

Study ID

NCT00394628

Start date

Oct, 2006

Status verified date

May, 2007

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Histologically proven intracranial Glioblastoma Multiforme (GBM) with diagnosis established by biopsy or resection within 5 weeks prior to enrollment.
  • Cranial MRI or contrast CT performed 14 days prior to study entry. Subjects without measurable or assessable disease are eligible.
  • Plan to begin partial brain radiotherapy within 24-72 hours after beginning AQ4N, and within 35 days (5 weeks) of the surgery, or if surgery cannot be performed, the biopsy that confirms GBM diagnosis. Radiation therapy must be given by external beam to a partial brian field in daily fractions of 2.0 Gy, to a planned total dose to the tumor of 60.0 Gy over 6 weeks.
  • Age equal to or greater than 18 years and life expectancy > 10 weeks.
  • Karnofsky performance status of > 60.
  • Adequate bone marrow, liver and renal functions (tests must be performed within 14 days prior to enrollment).
  • Negative serum or urine pregnancy test (females of childbearing potential only).
  • Willingness to use effective contraception (both males and females of child-bearing potential) throughout the study and for at least 2 months after study treatment.
  • Able and willing to give informed consent.

Exclusion Criteria:

  • Previous radiotherapy to the brain.
  • Previous cytotoxic drug therapy, non-cytotoxic drug therapy, or experimental drug therapy directed against the brain tumor. Subjects who received Gliadel wafers will be excluded.
  • Subjects previously treated with enzyme-induced antiepileptic drugs (EIAEDs) must have discontinued treatment with these agent(s) greater than or equal to 2 weeks prior to enrollment.
  • A history of any other primary malignancy that has not been treated with curative intent and that has not been in complete remission for at least 2 years (exempt from the two year limit are non-melanoma skin cancer and cervical carcinoma in-situ on biopsy or a squamous intraepithelial lesion on PAP smear).
  • Active infection.
  • Any significant medical illnesses or toxicities that in the investigator's opinion cannot be adequately controlled with appropriate therapy or would compromise the subjects' ability to tolerate this therapy. Subjects must not have any disease that will obscure toxicity or dangerously alter drug metabolism, e.g. congestive heart failure, moderate to severe liver and renal disease, other cancers.
  • Cardiac ejection fraction (LVEF) by multiple gated acquisition scan (MUGA) less than the institutional lower limit of normal.
  • Prior investigational therapy within the past 28 days.
  • Prior AQ4N therapy.
  • Hypersensitivity to AQ4N or to any ingredients contained in the drug formulation.
  • Hypersensitivity to temozolomide or to any ingredients contained in the drug formulation and dacarbazine (DTIC).
  • Pregnant or lactating women.

Study Design

Enrollment

60 participants

Anticipated

Allocation

Non randomized

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Interventions

AQ4N

Temozolomide

Radiotherapy

Primary outcome measure

  • Phase 1b: Evaluation of the safety and tolerability of AQ4N in combination with radiation therapy and temozolomide (TEMODAR®)for the treatment of glioblastoma multiforme (GBM). Dose levels for the Phase 2a will be selected. [ Time Frame: undefined ]
  • Phase 2a: Rate of progression-free survival at 6 months. [ Time Frame: undefined ]

Central Contacts and Locations

Locations

University of California, Los Angeles

Recruiting

Los Angeles, California, United States

Contacts

Emese Filka

310-794-3521

Principal Investigator:

Tim Clughsey, MD

Northwestern University Feinberg School of Medicine

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Lilia Gallot

312-695-1363

Principal Investigator:

Jeffrey Raizer, MD

Henry Ford Health Systems

Recruiting

Detroit, Michigan, United States, 48202

Contacts

Ruth Ann Beasse

313-916-3731rbeasse1@hfhs.org

Principal Investigator:

Tom Mikkelsen, MD

Duke University Medical Center

Recruiting

Durham, North Carolina, United States, 27710

Contacts

Velmeca McCrea

919-684-5632velmeca.mccrea@duke.edu

Principal Investigator:

David Reardon, MD

Baylor Research Institute

Recruiting

Dallas, Texas, United States

Contacts

Stephanie Peschka, RN

214-820-8685

Principal Investigator:

Karen Fink, MD

More Information

Sponsor

Novacea

Last update posted

May 30, 2007

Last verified

May, 2007

Keywords

  • Glioblastoma Multiforme
  • Radiotherapy
  • temozolomide
  • adjuvant temozolomide

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Novacea on 2007-05-30.