Recruiting
Phase 2
Phase 3

CBT & D-Cycloserine

Sponsor:

Université de Montréal

Code:

NCT00452231

Conditions

Post-Traumatic Stress Disorder

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

D-cycloserine

Cognitive-Behavioral Therapy

Study Details

Brief summary:

The purpose of this study is to investigate if the effectiveness of cognitive-behavioral therapy for post-traumatic stress disorder can be increased by combining it with D-cycloserine (TCC/D-cycloserine) by comparing with a placebo (TCC/placebo).

Conditions

Post-Traumatic Stress Disorder

Study ID

NCT00452231

Start date

Feb, 2007

Status verified date

Mar, 2007

Completion date

Jul, 2008

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Clinical diagnosis of PTSD
  • No other Axix I disorder of higher intensity than PTSD
  • Accept not to start a psychopharmacological treatment before and during the participation to the project

Exclusion Criteria:

  • Substance abuse
  • Psychotic episodes (past or current)
  • Bipolar disorder
  • Organic caused mental disorder
  • Intellectual deficiency
  • Pregnant or breast-feeding woman
  • Épilepsy

Study Design

Enrollment

20 participants

Allocation

Randomized

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Interventions

D-cycloserine

Cognitive-Behavioral Therapy

Primary outcome measure

  • Clinician-administered measures collected at initial assessment, post-treatment and six-months follow-up: [ Time Frame: undefined ]
  • CAPS: PTSD symptoms [ Time Frame: undefined ]
  • SCID: AXIS I disorders [ Time Frame: undefined ]

Central Contacts and Locations

Central contacts

Sarah Jane Parent

(514) 251-4000sparent.hlhl@ssss.gouv.qc.ca

Cindy Beaudoin

(514) 251-4000beaudoincindy@hotmail.com

Locations

Centre d'étude sur le Trauma

Recruiting

Montréal, Quebec, Canada, H1N 3V2

Contacts

Stéphane Guay, Ph.D.

(514) 251-4000stephane.guay@umontreal.ca

André Marchand, Ph.D.

(514) 251-4000amarchand.hlhl@ssss.gouv.qc.ca

Principal Investigator:

Stéphane Guay, Ph.D.

More Information

Sponsor

Université de Montréal

Last update posted

Mar 27, 2007

Last verified

Mar, 2007

Keywords

  • Post-traumatic Stress Disorder
  • Cognitive-Behavioral Therapy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Université de Montréal on 2007-03-27.