Recruiting
Phase 3

Coronary Angiography

Sponsor:

Vancouver General Hospital

Code:

NCT00473863

Conditions

Acute Coronary Syndrome

Acute Myocardial Infarction

Unstable Angina

Coronary Disease

Coronary Stenosis

Eligibility Criteria

Sex: All

Age: 19+

Healthy Volunteers: Not accepted

Interventions

Coronary Computed Tomographic Angiography

Study Details

Brief summary:

The purpose of this study is to determine whether Coronary Computed Tomographic Angiography (CCTA) will increase patient safety by decreasing the rate of missed ACS and adverse events in patients who receive standard care plus CCTA versus standard care alone. Additional goals of the study are to determine whether CCTA can safely reduce the duration of ED visits and the number and duration of hospital admissions.

Conditions

Acute Coronary Syndrome

Acute Myocardial Infarction

Unstable Angina

Coronary Disease

Coronary Stenosis

Study ID

NCT00473863

Start date

Nov, 2007

Status verified date

Nov, 2007

Completion date

Jul, 2008

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19+

Healthy Volunteers: Not accepted

Inclusion criteria (all of the following):

  • Anterior or lateral chest pain
  • 19 years of age or older
  • Fixed address in British Columbia
  • Available for telephone follow-up

Exclusion criteria (any of the following).

  • Low Risk for ACS (all of the following):
  • Age < 40 years with normal ECG (T wave flattening is the only acceptable abnormality)
  • No prior history of ischemic chest pain (defined as a past diagnosis of MI or angina, previously prescribed nitroglycerine or a clear history of effort related angina)
  • High Risk for ACS (any of the following):
  • Diagnosis consistent with ST elevation myocardial infarction
  • New ST depression ≥ 0.05 mV
  • Troponin > 0.1
  • Patients with Killip class III or IV heart failure.
  • Hemodynamic instability
  • Previous enrolment in this study.
  • Presence of terminal noncardiac illness.
  • History of angioplasty with stenting and/or grafts.
  • Presence of atrial fibrillation.
  • Contraindication to administration of iodinated contrast agent.
  • Contraindication to beta-blocker administration (eg, asthmatics) AND calcium channel blocker administration.
  • Glomerular filtration rate less than 60 mL/min.
  • Previous ECG-gated CT with calcium score >1000 Agatston Units.
  • Pregnancy.
  • Patients with communication difficulties.
  • Patients who have a clear alternative diagnosis other than ischemic chest pain (e.g. traumatic chest pain or pneumonia).

Study Design

Enrollment

150 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: intervention

Receives CCTA

no intervention: Control

Interventions

Coronary Computed Tomographic Angiography

CCTA will be performed

Primary outcome measure

  • Emergency Department Admission Time [ Time Frame: During initial presentation to hospital ]

Central Contacts and Locations

Central contacts

William F Dick, MD

604 875 4700william.dick@vch.ca

Locations

VGH

Recruiting

Vancouver, British Columbia, Canada, V5Z1M9

Contacts

William Dick, MD

604 875 4700william.dick@vch.ca

More Information

Sponsor

Vancouver General Hospital

Last update posted

Nov 20, 2007

Last verified

Nov, 2007

Keywords

  • Acute coronary syndrome
  • Acute myocardial infarction
  • Unstable angina
  • Coronary computed tomographic angiography
  • Coronary Angiography
  • Tomography, X-Ray Computed
  • Tomography, Spiral Computed

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Vancouver General Hospital on 2007-11-20.