Inclusion Criteria:
Patients must meet ALL of the following criteria:
- The patients must be >18 years of age
- Patients must have been referred for percutaneous coronary intervention (PCI)
- Diagnosis of angina pectoris defined by Canadian Cardiovascular Society Classification (CCS I, II, III, IV) OR unstable angina pectoris (Braunwald Classification B\&C, I-II-III) OR patients with documented silent ischemia;
- Treatment of lesions in native coronary vessels or bypass grafts requiring angioplasty or stenting.
- Patient is willing to comply with the specified follow-up evaluation;
- Patient must provide written informed consent prior to the procedure using a form that is approved by the local Institutional Review Board.
Exclusion Criteria:
Patients will be excluded if ANY of the following conditions apply:
- Patient has experienced an ST-segment elevation myocardial infarction within the preceding 24 hours.
- Active internal bleeding or bleeding diathesis, surgery, trauma, or gastrointestinal or genitourinary tract bleeding within past 6 weeks; prior intracranial bleeding; or platelet count<100,000
- Woman of child-bearing potential unless demonstrated negative pregnancy test
- End Stage Renal Disease requiring hemodialysis
- Recipient of heart transplant;
- Current treatment with 1) intravenous unfractionated heparin or treatment with low molecular weight heparin within past 8 hours; 2)bivalirudin; 3)abciximab; 4)eptifibatide; or tirofiban
- Ongoing need for warfarin or heparin therapy
- Known allergies to aspirin, clopidogrel bisulfate (Plavix®) and/or heparin;
- Any significant medical condition which in the investigator's opinion may interfere with the patient's optimal participation in the study;
- Currently participating in an investigational drug or another device study;
- Any contraindication to glycoprotein IIb/IIIa inhibitor (eptifibatide (Integrilin®)) or bivalirudin therapy;
- Chronic or relapse/remitting hemolytic condition or pre-catheterization hematocrit<30 mg/dl
- Unprotected left main coronary disease with >50% stenosis;
- Platelet count <150,000