Recruiting

Observational Study

Sponsor:

University of Calgary

Code:

NCT00522496

Conditions

Brain Injuries, Traumatic

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to:

1. Determine the temporal course of matrix metalloproteinase (MMP) expression in patients wiht severe traumatic brain injury
2. Determine the temporal course of the expression of MMP-related inflammatory mediators of secondary injury in patients with severe traumatic brain injury
3. Describe the association of physiological changes and standard microdialysis analyte measures (lactate, pyruvate, lactate/pyruvate ratio, and glucose) to MMP and neuroinflammatory marker concentrations.

Conditions

Brain Injuries, Traumatic

Study ID

NCT00522496

Start date

Jul, 2007

Status verified date

Feb, 2009

Completion date

Aug, 2009

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patient is 18 years of age or older
  • Patient has GCS less than 9
  • Patient requires intracranial pressure monitoring
  • Patient life expectancy greater than 72 hours

Exclusion Criteria:

  • Patient's TBI is greater than 24 hours old
  • Patient is less than 18 years of age
  • Patient does not require intracranial pressure monitoring
  • Patient has life expectancy less than 72 hours
  • Patient has GCS greater or equal to 9
  • Patient is currently enrolled in another study

Study Design

Enrollment

8 participants

Anticipated

Interventions and Outcome Measures

Central Contacts and Locations

Central contacts

David A Zygun, MD

403-944-1691dzygun@ucalgary.ca

Locations

Foothills Medical Centre

Recruiting

Calgary, Alberta, Canada, T2N 2T9

Contacts

David A Zygun, MD

403-944-1691dzygun@ucalgary.ca

Principal Investigator:

David A Zygun, MD

More Information

Sponsor

University of Calgary

Last update posted

Feb 24, 2009

Last verified

Feb, 2009

Keywords

  • Craniocerebral trauma
  • matrix metalloproteinase
  • microdialysis

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Calgary on 2009-02-24.