Recruiting

Observational Study

Sponsor:

Northwestern University

Code:

NCT00537004

Conditions

Primary Progressive Aphasia

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.

Conditions

Primary Progressive Aphasia

Study ID

NCT00537004

Start date

May, 2007

Status verified date

Feb, 2026

Completion date

Apr, 2027

Anticipated

Primary completion date

Apr, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of primary progressive aphasia
  • Right-handed
  • Native English speaker
  • Visual acuity of 20/30 corrected
  • Adequate hearing to follow conversation
  • Safe for an MRI scan

Exclusion Criteria:

  • Left-handedness
  • Claustrophobia
  • Presence of significant medical illness that initially or in the future could interfere with continued participation in the study

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Arms

PPA (Primary Progressive Aphasia)

Individuals with primary progressive aphasia

Control

Individuals with no diagnosis of any type of dementia

Primary outcome measure

  • Neuropsychological variables [ Time Frame: Immediately after testing and at two years post-testing ]

Central Contacts and Locations

Central contacts

Elizabeth A Haynes

312-503-2398PPA.Research@northwestern.edu

Locations

Northwestern University

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Seyi Adeolu

312-503-2398PPA.Research@northwestern.edu

Principal Investigator:

M.-Marsel Mesulam, MD

More Information

Sponsor

Northwestern University

Last update posted

Feb 27, 2026

Last verified

Feb, 2026

Keywords

  • primary progressive aphasia
  • frontotemporal dementia
  • semantic dementia
  • progressive nonfluent aphasia
  • progressive aphasia
  • frontotemporal lobar degeneration

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Northwestern University on 2026-02-27.