Recruiting

Observational Study

Sponsor:

Vanderbilt University Medical Center

Code:

NCT00575081

Conditions

Parkinson's Disease

Obsessive Compulsive Disorder

Dystonia

Essential Tremor

Epilepsy

Eligibility Criteria

Sex: All

Age: 6 - 70+

Healthy Volunteers: Not accepted

Interventions

Stereotactic brain procedures

Study Details

Brief summary:

The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essential Tremor, and OCD, but now includes data acquired during all stereotactic brain procedures.

Conditions

Parkinson's Disease

Obsessive Compulsive Disorder

Dystonia

Essential Tremor

Epilepsy

Study ID

NCT00575081

Start date

Aug, 2006

Status verified date

Aug, 2026

Completion date

Aug, 2027

Anticipated

Primary completion date

Aug, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 6 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • All patients who are recommended for Stereotactic Brain procedures
  • Any patient who has agreed to undergo a Stereotactic Brain procedure
  • Patients age under 6 -90 years old

Exclusion Criteria:

  • Patients who fail recommendation for Stereotactic Brain procedures
  • Patients not consented for Stereotactic Brain procedures
  • Patients outside the age range of 6 -90 years old
  • Patients or legal guardians not able to provide informed consent

Study Design

Enrollment

5000 participants

Anticipated

Interventions and Outcome Measures

Arms

Stereotactic Brain Procedures

Patients who have consented to undergo or have undergone a stereotactic brain procedure for any reason including those who need Deep Brain Stimulation, SEEG or other brain neurmodulation device implant.

Interventions

Stereotactic brain procedures

Stereotactic brain procedures

Primary outcome measure

  • To create an atlas that will allow physiological information to be assigned to anatomical locations in MRI space, utilizing non-rigid MRI normalization algorithms. [ Time Frame: life of study ]

Central Contacts and Locations

Central contacts

Dario J Englot, MD, Ph.D.

615-322-7417dario.englot@vumc.org

Wuraola a Adesinasi

wuraola.a.adesinasi@vumc.org

Locations

Vanderbilt Univeristy

Recruiting

Nashville, Tennessee, United States, 37232

Contacts

Dario J Englot, MD, Ph.D.

615-322-7417dario.englot@vumc.org

Wuraola T Adesinasi@vumc.org

wuraola.a.adesinasi@vumc.org

More Information

Sponsor

Vanderbilt University Medical Center

Last update posted

Aug 26, 2026

Last verified

Aug, 2026

Keywords

  • Physiological Brain Atlas, Brain registry, Brain database

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Vanderbilt University Medical Center on 2026-08-26.