Recruiting

Glucose Infusion

Sponsor:

McGill University Health Centre/Research Institute of the McGill University Health Centre

Code:

NCT00623662

Conditions

Hepatic Insufficiency

Liver Failure

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Preoperative glucose infusion

Preoperative normal saline infusion

Study Details

Brief summary:

The goal of the study is to determine whether intravenous glucose administration before liver resection preserves hepatic glycogen resulting in improved hepatic metabolic function after the operation.

We further investigate whether the benefit of avoiding preoperative fasting is more pronounced in patients undergoing more extensive liver resection.

Conditions

Hepatic Insufficiency

Liver Failure

Study ID

NCT00623662

Start date

Feb, 2008

Status verified date

Apr, 2018

Completion date

Mar, 2019

Anticipated

Primary completion date

Mar, 2019

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • American Society of Anesthesiologists class ≤3
  • liver resection (one or more liver segments) for primary or secondary malignancy
  • ability to give informed consent

Exclusion Criteria:

  • signs of severe malnutrition or obesity: body mass index (BMI) <20 or >30 kg.m-2, more than 10% involuntary body weight loss over the preceding six months, serum albumin <35 g.L-1
  • chronic viral liver disease
  • diabetes mellitus
  • significant cardiorespiratory, renal and neurological disease
  • musculoskeletal or neuromuscular disease
  • severe anemia (hemoglobin <10 g.dL-1)
  • history of severe sciatica or back surgery or other conditions which contraindicate the use of an epidural catheter

Study Design

Enrollment

50 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

active comparator: 1

Glucose infusion.

placebo comparator: 2

Normal saline infusion.

Interventions

Preoperative glucose infusion

Glucose infusion from 15:00 on the day before the operation until beginning of surgery.

Preoperative normal saline infusion

Normal saline infusion from 15:00 on the day before surgery until beginning of the operation.

Primary outcome measure

  • Rate of albumin synthesis [ Time Frame: One day before and one day after surgery ]

Central Contacts and Locations

Central contacts

Ralph Lattermann, MD PhD

514-934-1934ralph.lattermann@muhc.mcgill.ca

Thomas Schricker, MD PhD

514-934-1934thomas.schricker@mcgill.ca

Locations

Royal Victoria Hospital, McGill University Health Centre

Recruiting

Montreal, Quebec, Canada, H3A 1A1

Contacts

Ralph Lattermann, MD PhD

514-934-1934ralph.lattermann@muhc.mcgill.ca

Thomas Schricker, MD PhD

514-934-1934thomas.schricker@mcgill.ca

Principal Investigator:

Ralph Lattermann, MD PhD

More Information

Sponsor

McGill University Health Centre/Research Institute of the McGill University Health Centre

Last update posted

Apr 3, 2018

Last verified

Apr, 2018

Keywords

  • Glucose infusion
  • Liver function
  • Liver resection
  • Albumin synthesis
  • Stable isotopes

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by McGill University Health Centre/Research Institute of the McGill University Health Centre on 2018-04-03.