Recruiting

Observational Study

Sponsor:

Laval University

Code:

NCT00686452

Conditions

Asthma

Airway Hyperresponsiveness

Eligibility Criteria

Sex: All

Age: 14 - 35

Healthy Volunteers: Accepted

Study Details

Brief summary:

Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are

1. to compare the prevalence of asthma in swimmers and control subjects
2. to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects
3. to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training

Conditions

Asthma

Airway Hyperresponsiveness

Study ID

NCT00686452

Start date

Mar, 2007

Status verified date

May, 2008

Completion date

May, 2009

Anticipated

Primary completion date

May, 2009

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 14 - 35

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 14 to 35 years old
  • To swim at least 10h per week
  • For control subjects, non-competitive healthy subjects

Exclusion Criteria:

  • any disease that may interfere with the tests for the controls
  • Triathletes are excluded
  • Smokers
  • Obese or with a BMI more than 29
  • Former athletes (control group)

Study Design

Enrollment

100 participants

Anticipated

Interventions and Outcome Measures

Arms

1

Swimmers without AHR

2

Swimmers with asymptomatic AHR

3

Swimmers with symptomatic AHR and use only of beta-2 adrenargic

4

Swimmers with asthma and inhaled corticosteroids

5

Healthy Subjects

6

Healthy subjects with AHR

7

Healthy subjects with symptomatic AHR (asthma) but without treatment

Primary outcome measure

  • Asthma and airway hyperreactivity prevalence in swimmers [ Time Frame: 3 measurements in the year ]

Central Contacts and Locations

Central contacts

Valérie BOUGAULT, PhD

418-656-8711valerie.bougault@crhl.ulaval.ca

Louis-Philippe BOULET, MD

418-656-4747lpboulet@crhl.ulaval.ca

Locations

Centre de recherche en pneumologie et en cardiologie de l'hôpital Laval

Recruiting

Québec, Quebec, Canada, G1V4G5

Contacts

Valerie BOUGAULT, PhD

418-656-8711valerie.bougault@crhl.ulaval.ca

Louis-Philippe BOULET, MD

lpboulet@crhl.ulaval.ca

Principal Investigator:

Louis-Philippe BOULET, MD

More Information

Sponsor

Laval University

Last update posted

Dec 22, 2008

Last verified

May, 2008

Keywords

  • Asthma
  • Airway hyperresponsiveness
  • Swimmers
  • Airway inflammation
  • Airway remodelling

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Laval University on 2008-12-22.