Recruiting

Observational Study

Sponsor:

University of Utah

Code:

NCT00722527

Conditions

Polycythemia

Thrombocytosis

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Our study is designed to characterize the clinical picture and genetic pattern of Polycythemia and Thrombocytosis. The purpose of this project is to find a gene and its mutation that causes these disorders. When this is accomplished, new therapies to control and eventually cure the disorder can be designed.

Conditions

Polycythemia

Thrombocytosis

Study ID

NCT00722527

Start date

Jul, 2006

Status verified date

Mar, 2026

Completion date

Jul, 2028

Anticipated

Primary completion date

Jul, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Subjects with an elevated hemoglobin concentration (>18 in males and >16 in females)
2. Subjects with an elevated platelet count (>450,000)

Exclusion Criteria:

1. Subjects who have a known acquired cause of polycythemia and thrombocytosis
2. Subjects with heart disease, left to right heart shunt or severe pulmonary disease

Study Design

Enrollment

200 participants

Anticipated

Interventions and Outcome Measures

Arms

Affected Population

Subjects with an elevated hemoglobin concentration or an elevated platelet count

Primary outcome measure

  • Identify the molecular defect of Polycythemic and Thrombocythemic disorders [ Time Frame: Weekly ]

Central Contacts and Locations

Central contacts

Josef T Prchal, MD

801-581-4220josef.prchal@hsc.utah.edu

Soo Jin Kim, MS

801-213-4379soo.kim@hsc.utah.edu

Locations

University of Utah

Recruiting

Salt Lake City, Utah, United States, 84132

Contacts

Josef T Prchal, MD

801-581-4220josef.prchal@hsc.utah.edu

Soo Jin Kim, MS

801-213-4379soo.kim@hsc.utah.edu

Principal Investigator:

Josef T Prchal, MD

More Information

Sponsor

University of Utah

Last update posted

Mar 9, 2026

Last verified

Mar, 2026

Keywords

  • Primary Familial and Congenital Polycythemia
  • Polycythemia
  • Molecular Biology
  • Genetics
  • Erythropoiesis
  • EPOR mutation
  • Thrombocytosis
  • Hypoxia

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Utah on 2026-03-09.