Recruiting

Pharmacogenetics

Sponsor:

St. Jude Children's Research Hospital

Code:

NCT00730678

Conditions

All Malignancies

Children Being Treated for Catastrophic Illness

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Study Details

Brief summary:

To investigate whether genetic polymorphisms in genes encoding proteins involved in the metabolism or effects of drugs or environmental agents influence the disposition or effects of these xenobiotic substrates. To investigate the nature of heritability and the genetic basis of pharmacogenetic traits by studying family members of individuals with specific genotypes.

Conditions

All Malignancies

Children Being Treated for Catastrophic Illness

Study ID

NCT00730678

Start date

Aug 17, 1998

Status verified date

Apr, 2026

Completion date

Mar, 2034

Anticipated

Primary completion date

Dec, 2033

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Any patients under evaluation/treatment at St. Jude Children's Research Hospital (SJCRH)
  • Parents or family members of St. Jude patients
  • Non patient volunteers
  • All study subjects must provide informed consent for participation
  • Assent/Consent of the patient (parent) must be provided prior to attempts made by investigators to enroll a family member of a SJCRH patient

Exclusion Criteria:

Study Design

Enrollment

8800 participants

Anticipated

Interventions and Outcome Measures

Arms

All Participants

All participants enrolled on this study will have blood drawn for genetic testing.

Primary outcome measure

  • To investigate whether genetic polymorphisms in genes encoding proteins involved in the metabolism or effects of drugs or environmental agents influence the disposition or effects of these xenobiotic substrates. [ Time Frame: 28 years ]

Central Contacts and Locations

Central contacts

Jun J. Yang, Ph. D.

888-226-4343referralinfo@stjude.org

Locations

St. Jude Children's Research Hospital

Recruiting

Memphis, Tennessee, United States, 38105

Contacts

Jun J. Yang, Ph. D.

888-226-4343referralinfo@stjude.org

Principal Investigator:

Jun J. Yang, Ph. D.

More Information

Sponsor

St. Jude Children's Research Hospital

Last update posted

Apr 29, 2026

Last verified

Apr, 2026

Keywords

  • Metabolism
  • Pharmacogenetic testing

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by St. Jude Children's Research Hospital on 2026-04-29.