Recruiting

Photoacoustic Tomography

Sponsor:

University of Michigan

Code:

NCT00748254

Conditions

Arthritis, Rheumatoid

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Laser Based Photoacoustic Tomography, MRI, Ultrasound

laser based photoacoustic tomography, MRI, ultrasound

Study Details

Brief summary:

The purpose of this feasibility study is to determine if a new emerging technology called photoacoustic tomography (PAT) can be adapted for use in humans for the detection of chronic rheumatoid arthritis.

Conditions

Arthritis, Rheumatoid

Study ID

NCT00748254

Start date

Dec 1, 2011

Status verified date

Jan, 2026

Completion date

Jan, 2027

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Men and women 18 years of age or older can participate in this study.
  • Patients can participate in this study if they have had rheumatoid arthritis for more than 2 years and their rheumatologist has referred them to this study.
  • Patients can participate as a healthy volunteer with a known history of rheumatoid arthritis.

Exclusion Criteria:

  • Patients, who have electrically, magnetically or mechanically activated implants such as heart pacemaker, magnetic surgical clips, prostheses or implanted neurological stimulator.
  • Pregnant patients.
  • Patients who is claustrophobic.
  • Patients with impaired renal function cannot participate in this study such as elevate creatinine clearance, patients on kidney dialysis etc.
  • Patients with shock hypotension or unstable low blood pressure.
  • Patients with Rhabdomyolysis.
  • Patients who have had a contrast enhanced (with gadolinium) MRA (magnetic resonance angiography)/ or MRI within the last 3 months. (Contrast is a medication injected into a vein during a imaging examination that helps produce clearer images/pictures).

Study Design

Enrollment

113 participants

Anticipated

Interventions and Outcome Measures

Arms

Rheumatoid Arthritis

Patients who have active disease affecting the joints in the hand will have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound

Normal controls

Healthy volunteers who do not have arthritis will also have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound on the joints of their hand

Interventions

Laser Based Photoacoustic Tomography, MRI, Ultrasound

Healthy subjects will have scans on finger joints with any of the scanning methods described above.

laser based photoacoustic tomography, MRI, ultrasound

Subjects with arthritis will have scans on finger joints with any of the scanning methods described above.

Primary outcome measure

  • Photoacoustic Imaging [ Time Frame: 10 weeks ]

Central Contacts and Locations

Central contacts

Safa Mohamed

734 615-1646safam@med.umich.edu

Locations

Universtity of Michigan Health System

Recruiting

Ann Arbor, Michigan, United States, 48109

Principal Investigator:

Xueding Wang, PHD

More Information

Sponsor

University of Michigan

Last update posted

Jan 23, 2026

Last verified

Jan, 2026

Keywords

  • Rheumatoid arthritis

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Michigan on 2026-01-23.