Recruiting

Observational Study

Sponsor:

St. Jude Children's Research Hospital

Code:

NCT00760656

Conditions

Cancer

Eligibility Criteria

Sex: All

Age: 5+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Childhood cancer predisposes to health risks that may not become apparent until many years after completion of therapy. The SJLIFE protocol is designed to establish a lifetime cohort of childhood cancer survivors treated at St. Jude Children's Research Hospital to facilitate evaluation of health outcomes in aging adults surviving pediatric cancer.

The study focuses on the following Primary and secondary objectives:

  • To establish a lifetime cohort of childhood cancer survivors treated at St. Jude Children's Research Hospital to facilitate evaluation of health outcomes in aging children and adults surviving pediatric cancer.
  • To estimate the prevalence, cumulative incidence, and latency of selected late treatment complications following predisposing therapeutic exposures in children and adults surviving pediatric cancer.
  • To identify treatment, demographic, and psychosocial / behavioral related predictors of adverse health outcomes.
  • To develop risk profiles for adverse health outcomes across the age spectrum to guide development of clinical screening guidelines and risk-reducing interventions.
  • To identify factors that may be protective against the development of specific late treatment complications.
  • To generate data for a series of future hypothesis-driven trials
  • To serve as a source for the collection of samples from child and adult volunteers for future SJLIFE research.
  • To collect health outcomes data on a community control population for comparison purposes.
  • Characterize longitudinal social determinants of health (SDOH) to examine how living conditions, social integration, and structural inequality interact with personal social integrations/support to influence health.

Conditions

Cancer

Study ID

NCT00760656

Start date

Sep 13, 2007

Status verified date

Jun, 2026

Completion date

Dec 31, 2035

Anticipated

Primary completion date

Dec 31, 2035

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 5+

Healthy Volunteers: Not accepted

Survivor Inclusion Criteria:

  • Patient will have a diagnosis of childhood malignancy (or neoplasm requiring similar therapy) that was treated or followed at St. Jude Children's Research Hospital.
  • Patient will be at least five years from diagnosis.
  • Patient is willing to participate at any level of study
  • Patient is willing to comply with the guidelines of St. Jude domiciliary care facilities
  • Patient or legally authorized representative must sign informed consent for study participation.

Control Participant Inclusion Criteria:

  • ≥5 years of age
  • Non-first degree relatives or friends of St. Jude patients or former patients or SJCRH employees/affiliates who are not SJLIFE study team members, or family members of SJLIFE study team, or supervised by a SJLIFE study team members, or any volunteer not associated with St. Jude.
  • Participant does not have a diagnosis of childhood malignancy or childhood neoplasm requiring similar therapy (i.e., diagnosed <21 years of age).
  • Participant is not currently pregnant or lactating.
  • Patient is willing to comply with the guidelines of St. Jude domiciliary care facilities.
  • Patient must sign informed consent for study participation.

Gait and Mobility Lab Assessment Inclusion Criteria:

  • Enrolled participant in the SJLIFE study.
  • At-risk for long lasting difficulties with walking or other aspects of mobility.
  • Participant is not currently pregnant.
  • Participant or their designee signs informed consent for Gait and Mobility Lab Assessment participation.

Survivor/Control Exclusion Criteria:

  • Patient or control subject refuses to participate at any level of study

Gait and Mobility Lab Assessment Exclusion Criteria:

  • Prospective participant or their designee declines participation in the Gait and Mobility Lab Assessment.

Study Design

Enrollment

10000 participants

Anticipated

Interventions and Outcome Measures

Arms

Research Participants

Participants with a diagnosis of childhood malignancy treated or followed at SJCRH

Control Participants

Siblings, parents, relatives or friends of St. Jude patients or former patients or SJCRH employees who are not SJLIFE study team members or supervised by a SJLIFE study team members

Primary outcome measure

  • To establish a lifetime cohort of childhood cancer survivors treated at St. Jude Children's Research Hospital to facilitate evaluation of health outcomes in aging children and adults surviving pediatric cancer. [ Time Frame: Until the last participant withdraws, is taken off study, or dies (up until December 2025) up to 20 years ]

Central Contacts and Locations

Central contacts

Melissa Hudson, MD

888-226-4343referralinfo@stjude.org

Locations

St. Jude Children's Research Hospital

Recruiting

Memphis, Tennessee, United States, 38105

Contacts

Melissa M Hudson, MD

888-226-4343referralinfo@stjude.org

Principal Investigator:

Melissa M Hudson, MD

More Information

Sponsor

St. Jude Children's Research Hospital

Last update posted

Jun 17, 2026

Last verified

Jun, 2026

Keywords

  • Health outcomes in adults who survived pediatric cancer
  • Survivors of Pediatric Cancer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by St. Jude Children's Research Hospital on 2026-06-17.