Recruiting

Observational Study

Sponsor:

UConn Health

Code:

NCT00762008

Conditions

Acute Decompensated Heart Failure

Heart Failure

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to contract normally. They may then be released into the blood and be detected by standard method in the research laboratory. Thus, the purpose of this study is to determine the relation between the change of these two proteins in the blood and the occurrence of acute heart failure. At this time, detection of an increase in these proteins in the blood is not known to be associated with any disease or heart failure.

Conditions

Acute Decompensated Heart Failure

Heart Failure

Study ID

NCT00762008

Start date

Dec, 2005

Status verified date

Aug, 2026

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Individuals aged >18yrs
  • stable or decompensated heart failure, irrespective of LVEF
  • decompensated heart failure clinical symptoms such as dyspnea, rales, edema, elevated jugular venous pressure, or ascites
  • Imaging evidence of heart failure (cardiomegaly, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures)
  • Healthy individuals with no prior history of heart attack or heart failure will be recruited to use as controls.

Exclusion Criteria:

  • Subjects who are unable to give informed consent
  • Subjects who had undergone cardiac or non-cardiac surgery in the 3 months before enrollment
  • Pregnant subjects are not excluded

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Arms

Heart Failure

Primary outcome measure

  • Hospitalization for acute heart failure, myocardial infarction, stroke or death. [ Time Frame: 3 years ]

Central Contacts and Locations

Central contacts

Kristen Siedlarz, MA

860-679-7549siedlarz@uchc.edu

Locations

University of Connecticut Health Center

Recruiting

Farmington, Connecticut, United States, 06030

More Information

Sponsor

UConn Health

Last update posted

Aug 17, 2026

Last verified

Aug, 2026

Keywords

  • biomarkers

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by UConn Health on 2026-08-17.