Recruiting

Observational Study

Sponsor:

UConn Health

Code:

NCT00762333

Conditions

Myocardial Infarction

Ischemia

Congestive Heart Failure

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The purpose of this research is to determine if two proteins in the blood are increased during acute myocardial infarction and whether their levels are higher in those who develop heart failure than those who do not. These two proteins are produced and potentially released when the heart muscle is damaged. They may then be released into the blood and be detected by standard method in the research laboratory. At this time, detection of an increase in these proteins in the blood is not known to be associated with any disease or myocardial infarction.

Conditions

Myocardial Infarction

Ischemia

Congestive Heart Failure

Study ID

NCT00762333

Start date

Jun, 2007

Status verified date

Aug, 2026

Completion date

Mar, 2027

Anticipated

Primary completion date

Mar, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • men and women, 18 years of age and over with acute myocardial infarction (determined by positive cardiac markers -CKMB/ troponin) with or without heart failure (dyspnea, rales, edema, elevated jugular venous pressure, ascites).
  • Heart failure can be diagnosed using imaging evidence such as dilated heart, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures
  • A control group of male subjects age 60 and older without history of MI or heart disease

Exclusion Criteria:

  • Subjects unable to give consent
  • Subjects who have undergone cardiac or non-cardiac surgery in the 3 months prior to enrollment

Study Design

Enrollment

550 participants

Anticipated

Interventions and Outcome Measures

Arms

Myocardial Infarction

Primary outcome measure

  • Hospitalization for acute myocardial infarction, stroke or death [ Time Frame: 3 years ]

Central Contacts and Locations

Central contacts

Kristen Siedlarz, MA

860-679-7549siedlarz@uchc.edu

Locations

University of Connecticut Health Center

Recruiting

Farmington, Connecticut, United States, 06030

Principal Investigator:

Bruce T. Liang, MD

More Information

Sponsor

UConn Health

Last update posted

Aug 17, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by UConn Health on 2026-08-17.