Recruiting

Observational Study

Sponsor:

University of North Carolina, Chapel Hill

Code:

NCT00807482

Conditions

Kartagener Syndrome

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The overall short-term goals of this project include the following: 1) identify the genes that are key to the function of respiratory cilia to protect the normal lung; and 2) the effects of genetic mutations that adversely affect ciliary function and cause primary ciliary dyskinesia (PCD), which results in life-shortening lung disease. The long-term goal of this project is to develop better understanding of the underlying genetic variability that adversely modifies ciliary function, and predisposes to common airway diseases, such as asthma and chronic obstructive pulmonary disease.

Conditions

Kartagener Syndrome

Study ID

NCT00807482

Start date

Jan, 2004

Status verified date

Jun, 2026

Completion date

Jun, 2027

Anticipated

Primary completion date

Jun, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Patients who have a high suspicion for the diagnosis of PCD, based on clinical features

Healthy Volunteers who have a family member with confirmed PCD.

Study Design

Enrollment

1800 participants

Anticipated

Interventions and Outcome Measures

Arms

1

People who have been definitively diagnosed with primary ciliary dyskinesia (PCD).

Primary outcome measure

  • This is not an interventional study [ Time Frame: This is not an interventional study ]

Central Contacts and Locations

Locations

The University of North Carolina at Chapel Hill

Recruiting

Chapel Hill, North Carolina, United States, 27599

Contacts

Kelli Sullivan

919-962-9786kelli_sullivan@med.unc.edu

More Information

Sponsor

University of North Carolina, Chapel Hill

Last update posted

Jun 29, 2026

Last verified

Jun, 2026

Keywords

  • Primary Ciliary Dyskinesia
  • Mucociliary Clearance
  • Genetic Mutation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of North Carolina, Chapel Hill on 2026-06-29.